Universität zu Köln

Zeitler, Magteld ORCID: 0000-0001-6241-9921 and Tass, Peter A. (2016). Anti-kindling Induced by Two-Stage Coordinated Reset Stimulation with Weak Onset Intensity. Front. Comput. Neurosci., 10. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1662-5188

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Abstract

Abnormal neuronal synchrony plays an important role in a number of brain diseases. To specifically counteract abnormal neuronal synchrony by desynchronization, Coordinated Reset (CR) stimulation, a spatiotemporally patterned stimulation technique, was designed with computational means. In neuronal networks with spike timing dependent plasticity CR stimulation causes a decrease of synaptic weights and finally anti-kindling, i.e., unlearning of abnormally strong synaptic connectivity and abnormal neuronal synchrony. Long-lasting desynchronizing aftereffects of CR stimulation have been verified in pre-clinical and clinical proof of concept studies. In general, for different neuromodulation approaches, both invasive and non-invasive, it is desirable to enable effective stimulation at reduced stimulation intensities, thereby avoiding side effects. For the first time, we here present a two-stage CR stimulation protocol, where two qualitatively different types of CR stimulation are delivered one after another, and the first stage comes at a particularly weak stimulation intensity. Numerical simulations show that a two-stage CR stimulation can induce the same degree of anti-kindling as a single-stage CR stimulation with intermediate stimulation intensity. This stimulation approach might be clinically beneficial in patients suffering from brain diseases characterized by abnormal neuronal synchrony where a first treatment stage should be performed at particularly weak stimulation intensities in order to avoid side effects. This might, e.g., be relevant in the context of acoustic CR stimulation in tinnitus patients with hyperacusis or in the case of electrical deep brain CR stimulation with sub-optimally positioned leads or side effects caused by stimulation of the target itself. We discuss how to apply our method in first in man and proof of concept studies.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Zeitler, Magteld UNSPECIFIED orcid.org/0000-0001-6241-9921 UNSPECIFIED Tass, Peter A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-275647
DOI:	10.3389/fncom.2016.00044
Journal or Publication Title:	Front. Comput. Neurosci.
Volume:	10
Date:	2016
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	1662-5188
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DEEP-BRAIN-STIMULATION; SUBTHALAMIC NUCLEUS STIMULATION; COUPLED PHASE OSCILLATORS; CHRONIC BILATERAL STIMULATION; STIMULUS-LOCKED RESPONSES; PARKINSONS-DISEASE; EFFECTIVE DESYNCHRONIZATION; DISTRIBUTED PRACTICE; SYNCHRONY; NETWORK Multiple languages Mathematical & Computational Biology; Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/27564