Universität zu Köln

Reinhardt, Andre and Neundorf, Ines ORCID: 0000-0001-6450-3991 (2016). Design and Application of Antimicrobial Peptide Conjugates. Int. J. Mol. Sci., 17 (5). BASEL: MDPI. ISSN 1422-0067

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Abstract

Antimicrobial peptides (AMPs) are an interesting class of antibiotics characterized by their unique antibiotic activity and lower propensity for developing resistance compared to common antibiotics. They belong to the class of membrane-active peptides and usually act selectively against bacteria, fungi and protozoans. AMPs, but also peptide conjugates containing AMPs, have come more and more into the focus of research during the last few years. Within this article, recent work on AMP conjugates is reviewed. Different aspects will be highlighted as a combination of AMPs with antibiotics or organometallic compounds aiming to increase antibacterial activity or target selectivity, conjugation with photosensitizers for improving photodynamic therapy (PDT) or the attachment to particles, to name only a few. Owing to the enormous resonance of antimicrobial conjugates in the literature so far, this research topic seems to be very attractive to different scientific fields, like medicine, biology, biochemistry or chemistry.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Reinhardt, Andre UNSPECIFIED UNSPECIFIED UNSPECIFIED Neundorf, Ines UNSPECIFIED orcid.org/0000-0001-6450-3991 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-276106
DOI:	10.3390/ijms17050701
Journal or Publication Title:	Int. J. Mol. Sci.
Volume:	17
Number:	5
Date:	2016
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	1422-0067
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Chemistry > Institute of Biochemistry
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CELL-PENETRATING PEPTIDE; GRAM-NEGATIVE BACTERIA; CATIONIC PEPTIDES; ANTIBACTERIAL PEPTIDES; ESCHERICHIA-COLI; AMINO-ACID; PROAPOPTOTIC PEPTIDE; THERAPEUTIC-USE; IONIC LIQUIDS; IN-VITRO Multiple languages Biochemistry & Molecular Biology; Chemistry, Multidisciplinary Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/27610