Becker, Jessica, May, Andrea, Gerges, Christian, Anders, Mario, Schmidt, Claudia, Veits, Lothar, Noder, Tania, Mayershofer, Rupert, Kreuser, Nicole, Manner, Hendrik, Venerito, Marino ORCID: 0000-0001-8581-0974, Hofer, Jan-Hinnerk, Lyros, Orestis, Ahlbrand, Constantin J., Arras, Michael, Hofer, Sebastian, Heinrichs, Sophie K. M., Weise, Katharina, Hess, Timo, Boehmer, Anne C., Kosiol, Nils, Kiesslich, Ralf, Izbicki, Jakob R., Hoelscher, Arnulf H., Bollschweiler, Elfriede, Malfertheiner, Peter, Lang, Hauke, Moehler, Markus, Lorenz, Dietmar, Ott, Katja, Schmidt, Thomas ORCID: 0000-0002-7166-3675, Noethen, Markus M., Hackelsberger, Andreas, Schumacher, Brigitte, Pech, Oliver, Vashist, Yogesh, Vieth, Michael, Weismueller, Josef, Knapp, Michael, Neuhaus, Horst, Roesch, Thomas, Ell, Christian, Gockel, Ines and Schumacher, Johannes ORCID: 0000-0001-9217-6457 (2016). The Barrett-associated variants at GDF7 and TBX5 also increase esophageal adenocarcinoma risk. Cancer Med., 5 (5). S. 888 - 892. HOBOKEN: WILEY. ISSN 2045-7634

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Abstract

Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) represent two stages within the esophagitis-metaplasia-dysplasia-adenocarcinoma sequence. Previously genetic risk factors have been identified that confer risk to BE and EAC development. However, to which extent the genetic variants confer risk to different stages of the BE/EAC sequence remains mainly unknown. In this study we analyzed three most recently identified BE variants at the genes GDF7 (rs3072), TBX5 (rs2701108), and ALDH1A2 (rs3784262) separately in BE and EAC samples in order to determine their risk effects during BE/EAC sequence. Our data show that rs3072 at GDF7 and rs2701108 at TBX5 are also associated with EAC and conclude that both loci confer disease risk also at later stages of the BE/EAC sequence. In contrast, rs3784262 at ALDH1A2 was highly significantly associated with BE, but showed no association with EAC. Our data do not provide evidence that the ALDH1A2 locus confers equal risk in early and late stages of BE/EAC sequence.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Becker, JessicaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
May, AndreaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gerges, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Anders, MarioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmidt, ClaudiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Veits, LotharUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Noder, TaniaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mayershofer, RupertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kreuser, NicoleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Manner, HendrikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Venerito, MarinoUNSPECIFIEDorcid.org/0000-0001-8581-0974UNSPECIFIED
Hofer, Jan-HinnerkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lyros, OrestisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ahlbrand, Constantin J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arras, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hofer, SebastianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heinrichs, Sophie K. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weise, KatharinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hess, TimoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boehmer, Anne C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kosiol, NilsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kiesslich, RalfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Izbicki, Jakob R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoelscher, Arnulf H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bollschweiler, ElfriedeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Malfertheiner, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lang, HaukeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moehler, MarkusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lorenz, DietmarUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ott, KatjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmidt, ThomasUNSPECIFIEDorcid.org/0000-0002-7166-3675UNSPECIFIED
Noethen, Markus M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hackelsberger, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schumacher, BrigitteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pech, OliverUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vashist, YogeshUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vieth, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weismueller, JosefUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Knapp, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Neuhaus, HorstUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roesch, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ell, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gockel, InesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schumacher, JohannesUNSPECIFIEDorcid.org/0000-0001-9217-6457UNSPECIFIED
URN: urn:nbn:de:hbz:38-276275
DOI: 10.1002/cam4.641
Journal or Publication Title: Cancer Med.
Volume: 5
Number: 5
Page Range: S. 888 - 892
Date: 2016
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 2045-7634
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
GENOME-WIDE ASSOCIATION; COMMON VARIANTS; LOCI; SUSCEPTIBILITY; DISEASE; DESIGNMultiple languages
OncologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/27627

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