Universität zu Köln

Lehmann, Helmar C. and Hoke, Ahmet (2016). Use of engineered Schwann cells in peripheral neuropathy: Hopes and hazards. Brain Res., 1638. S. 97 - 105. AMSTERDAM: ELSEVIER SCIENCE BV. ISSN 1872-6240

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Abstract

Many diseases of the peripheral nervous system affect the function of Schwann cells. Recent developments in stem cell technology offer the opportunity to engineer stem cell derived glial cell populations that reveal essential phenotypic characteristics of Schwann cells including growth support and myelination of peripheral axons. Potential applications of these cells include its use as platform for human cell-based disease models as well as potential source for cell transplantation strategies. In this review we provide an update on the latest developments in engineering Schwann cells as diagnostic tools or for cell replacement therapies in peripheral neuropathic conditions. This article is part of a Special Issue entitled PSC and the brain. (C) 2015 Elsevier B.V. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Lehmann, Helmar C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoke, Ahmet UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-276386
DOI:	10.1016/j.brainres.2015.10.040
Journal or Publication Title:	Brain Res.
Volume:	1638
Page Range:	S. 97 - 105
Date:	2016
Publisher:	ELSEVIER SCIENCE BV
Place of Publication:	AMSTERDAM
ISSN:	1872-6240
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PLURIPOTENT STEM-CELLS; MARIE-TOOTH-DISEASE; NEURAL CREST CELLS; NERVE REGENERATION; DIABETIC POLYNEUROPATHY; MOTOR-NEURONS; SENSORY NEURONS; DIRECTED DIFFERENTIATION; HEREDITARY NEUROPATHY; HUMAN FIBROBLASTS Multiple languages Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/27638