Bey, Katharina, Wolfsgruber, Steffen, Karaca, Ilker ORCID: 0000-0002-2139-0015, Wagner, Holger, Lardenoije, Roy, Becker, Julian, Milz, Esther, Kornhuber, Johannes ORCID: 0000-0002-8096-3987, Peters, Oliver, Froelich, Lutz, Huell, Michael, Ruether, Eckart, Wiltfang, Jens ORCID: 0000-0003-1492-5330, Riedel-Heller, Steffi, Scherer, Martin, Jessen, Frank, Maier, Wolfgang, van den Hove, Daniel L., Rutten, Bart P. F., Wagner, Michael ORCID: 0000-0003-2589-6440 and Ramirez, Alfredo ORCID: 0000-0003-4991-763X (2016). No association of the variant rs11887120 in DNMT3A with cognitive decline in individuals with mild cognitive impairment. Epigenomics, 8 (5). S. 593 - 599. LONDON: FUTURE MEDICINE LTD. ISSN 1750-192X

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Abstract

Alterations in DNA methylation have been associated with cognitive decline and Alzheimer's disease. A recent study of mild cognitive impairment (MCI) reported a significant association between annual decline in cognitive function and the rs11887120 SNP located in DNMT3A, a gene implicated in DNA methylation. Here, we aimed to replicate this finding in two independent MCI cohorts (n = 1024); however, no significant association was observed in either cohort or the pooled dataset. In stratified analyses for conversion to Alzheimer's disease status, no association between rs11887120 and cognitive decline was observed in either converters or nonconverters. In conclusion, our analyses provide no support for the hypothesis that genetic variants in DNMT3A are implicated in cognitive performance decline in individuals with MCI.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Bey, KatharinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wolfsgruber, SteffenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Karaca, IlkerUNSPECIFIEDorcid.org/0000-0002-2139-0015UNSPECIFIED
Wagner, HolgerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lardenoije, RoyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Becker, JulianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Milz, EstherUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kornhuber, JohannesUNSPECIFIEDorcid.org/0000-0002-8096-3987UNSPECIFIED
Peters, OliverUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Froelich, LutzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Huell, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruether, EckartUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wiltfang, JensUNSPECIFIEDorcid.org/0000-0003-1492-5330UNSPECIFIED
Riedel-Heller, SteffiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scherer, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jessen, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maier, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van den Hove, Daniel L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rutten, Bart P. F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wagner, MichaelUNSPECIFIEDorcid.org/0000-0003-2589-6440UNSPECIFIED
Ramirez, AlfredoUNSPECIFIEDorcid.org/0000-0003-4991-763XUNSPECIFIED
URN: urn:nbn:de:hbz:38-276606
DOI: 10.2217/epi-2015-0014
Journal or Publication Title: Epigenomics
Volume: 8
Number: 5
Page Range: S. 593 - 599
Date: 2016
Publisher: FUTURE MEDICINE LTD
Place of Publication: LONDON
ISSN: 1750-192X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
EPIGENETIC MECHANISMS; ALZHEIMERS-DISEASE; DNA METHYLATION; DIAGNOSIS; DEMENTIA; GERMANMultiple languages
Genetics & HeredityMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/27660

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