Universität zu Köln

Eichler, Christian, Fischer, Petra, Sauerwald, Axel ORCID: 0000-0002-9451-7726, Dahdouh, Faten and Warm, Mathias (2016). Flap adhesion and effect on postoperative complication rates using Tissuglu((R)) in mastectomy patients. Breast Cancer, 23 (3). S. 486 - 491. TOKYO: SPRINGER JAPAN KK. ISSN 1880-4233

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Abstract

Post-mastectomy seroma and related complications are common problems in modern oncological surgery. Occurrence rates of up to 59 % have been reported in literature. High-risk patients, that is, those who have undergone previous surgeries, present with a high body mass index, have had radiation or chemotherapy, present a particular challenge. Noninvasive measures such as fibrin-based sealants have thus far not been able to effectively reduce complications associated with fluid accumulation. A recent study using a lysine-derived urethane adhesive named TissuGlu(A (R)) however, showed promising results in patients after abdominoplasty. 32 consecutively recruited patients received a mastectomy using a gold standard mastectomy technique as well as TissuGlu(A (R)) flap fixation. A control group of 173 patients, having received a gold standard mastectomy-only, was analyzed retrospectively, totaling 205 patients. Primary endpoints were post-discharge seroma formation and revision surgery/re-hospitalization. Secondary endpoints were initial seroma volume, postoperative pain, hematoma formation and day of drain removal. No significant difference in seroma formation was demonstrated. The revision surgery/re-hospitalization rate was reduced from 6.9 to 0 %, though this did not reach significance. Significant improvement could be shown in the TissuGlu(A (R)) group regarding time to drain removal (17 % decrease), and hematoma formation (14 % decrease). No difference was shown in postoperative pain. Although patient numbers are still small, advantages in revision surgery/re-hospitalization rate, hematoma formation as well as time to drain removal was shown for the TissuGlu(A (R)) group. Therapeutic, IV.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Eichler, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Fischer, Petra UNSPECIFIED UNSPECIFIED UNSPECIFIED Sauerwald, Axel UNSPECIFIED orcid.org/0000-0002-9451-7726 UNSPECIFIED Dahdouh, Faten UNSPECIFIED UNSPECIFIED UNSPECIFIED Warm, Mathias UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-276924
DOI:	10.1007/s12282-015-0591-1
Journal or Publication Title:	Breast Cancer
Volume:	23
Number:	3
Page Range:	S. 486 - 491
Date:	2016
Publisher:	SPRINGER JAPAN KK
Place of Publication:	TOKYO
ISSN:	1880-4233
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PROGRESSIVE TENSION SUTURES; REDUCE LOCAL COMPLICATIONS; SURGICAL ADHESIVE; SEROMA FORMATION; BREAST Multiple languages Oncology; Obstetrics & Gynecology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/27692