Universität zu Köln

Martin, Bryn A. ORCID: 0000-0003-1234-7880, Yiallourou, Theresia I., Pahlavian, Soroush Heidari, Thyagaraj, Suraj, Bunck, Alexander C., Loth, Francis, Sheffer, Daniel B., Kroeger, Jan Robert and Stergiopulos, Nikolaos ORCID: 0000-0002-0519-0160 (2016). Inter-operator Reliability of Magnetic Resonance Image-Based Computational Fluid Dynamics Prediction of Cerebrospinal Fluid Motion in the Cervical Spine. Ann. Biomed. Eng., 44 (5). S. 1524 - 1538. NEW YORK: SPRINGER. ISSN 1573-9686

Full text not available from this repository.

Abstract

For the first time, inter-operator dependence of MRI based computational fluid dynamics (CFD) modeling of cerebrospinal fluid (CSF) in the cervical spinal subarachnoid space (SSS) is evaluated. In vivo MRI flow measurements and anatomy MRI images were obtained at the cervico-medullary junction of a healthy subject and a Chiari I malformation patient. 3D anatomies of the SSS were reconstructed by manual segmentation by four independent operators for both cases. CFD results were compared at nine axial locations along the SSS in terms of hydrodynamic and geometric parameters. Intraclass correlation (ICC) assessed the inter-operator agreement for each parameter over the axial locations and coefficient of variance (CV) compared the percentage of variance for each parameter between the operators. Greater operator dependence was found for the patient (0.19 < ICC < 0.99) near the craniovertebral junction compared to the healthy subject (ICC > 0.78). For the healthy subject, hydraulic diameter and Womersley number had the least variance (CV = similar to 2%). For the patient, peak diastolic velocity and Reynolds number had the smallest variance (CV = similar to 3%). These results show a high degree of inter-operator reliability for MRI-based CFD simulations of CSF flow in the cervical spine for healthy subjects and a lower degree of reliability for patients with Type I Chiari malformation.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Martin, Bryn A. UNSPECIFIED orcid.org/0000-0003-1234-7880 UNSPECIFIED Yiallourou, Theresia I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pahlavian, Soroush Heidari UNSPECIFIED UNSPECIFIED UNSPECIFIED Thyagaraj, Suraj UNSPECIFIED UNSPECIFIED UNSPECIFIED Bunck, Alexander C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Loth, Francis UNSPECIFIED UNSPECIFIED UNSPECIFIED Sheffer, Daniel B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kroeger, Jan Robert UNSPECIFIED UNSPECIFIED UNSPECIFIED Stergiopulos, Nikolaos UNSPECIFIED orcid.org/0000-0002-0519-0160 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-277331
DOI:	10.1007/s10439-015-1449-6
Journal or Publication Title:	Ann. Biomed. Eng.
Volume:	44
Number:	5
Page Range:	S. 1524 - 1538
Date:	2016
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1573-9686
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CHIARI-I MALFORMATION; CYCLIC CSF FLOW; FORAMEN MAGNUM; CAROTID BIFURCATION; CRANIOCERVICAL DECOMPRESSION; SUBARACHNOID SPACE; HUMAN BRAIN; SYRINGOMYELIA; REPRODUCIBILITY; HYDRODYNAMICS Multiple languages Engineering, Biomedical Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/27733