Universität zu Köln

Wunsch, Marie, Hohmann, Christopher, Milles, Bianca, Rostermund, Christina, Lehmann, Paul V., Schroeter, Michael, Bayas, Antonios, Ulzheimer, Jochen, Maeurer, Mathias, Erguen, Sueleyman and Kuerten, Stefanie (2016). The Correlation between the Virus- and Brain Antigen-Specific B Cell Response in the Blood of Patients with Multiple Sclerosis. Viruses-Basel, 8 (4). BASEL: MDPI AG. ISSN 1999-4915

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Abstract

There is a largely divergent body of literature regarding the relationship between Epstein-Barr virus (EBV) infection and brain inflammation in multiple sclerosis (MS). Here, we tested MS patients during relapse (n = 11) and in remission (n = 19) in addition to n = 22 healthy controls to study the correlation between the EBV-and brain-specific B cell response in the blood by enzyme-linked immunospot (ELISPOT) and enzyme-linked immunosorbent assay (ELISA). Cytomegalovirus (CMV) was used as a control antigen tested in n = 16 MS patients during relapse and in n = 35 patients in remission. Over the course of the study, n = 16 patients were untreated, while n = 33 patients received immunomodulatory therapy. The data show that there was a moderate correlation between the frequencies of EBV-and brain-reactive B cells in MS patients in remission. In addition we could detect a correlation between the B cell response to EBV and disease activity. There was no evidence of an EBV reactivation. Interestingly, there was also a correlation between the frequencies of CMV- and brain-specific B cells in MS patients experiencing an acute relapse and an elevated B cell response to CMV was associated with higher disease activity. The trend remained when excluding seronegative subjects but was non-significant. These data underline that viral infections might impact the immunopathology of MS, but the exact link between the two entities remains subject of controversy.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wunsch, Marie UNSPECIFIED UNSPECIFIED UNSPECIFIED Hohmann, Christopher UNSPECIFIED UNSPECIFIED UNSPECIFIED Milles, Bianca UNSPECIFIED UNSPECIFIED UNSPECIFIED Rostermund, Christina UNSPECIFIED UNSPECIFIED UNSPECIFIED Lehmann, Paul V. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schroeter, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Bayas, Antonios UNSPECIFIED UNSPECIFIED UNSPECIFIED Ulzheimer, Jochen UNSPECIFIED UNSPECIFIED UNSPECIFIED Maeurer, Mathias UNSPECIFIED UNSPECIFIED UNSPECIFIED Erguen, Sueleyman UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuerten, Stefanie UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-280782
DOI:	10.3390/v8040105
Journal or Publication Title:	Viruses-Basel
Volume:	8
Number:	4
Date:	2016
Publisher:	MDPI AG
Place of Publication:	BASEL
ISSN:	1999-4915
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language EPSTEIN-BARR-VIRUS; MOLECULAR MIMICRY; VIRAL PERSISTENCE; DISEASE-ACTIVITY; ANTIBODY-TITERS; INFECTION; CYTOMEGALOVIRUS; AUTOIMMUNITY; ACTIVATION; BYSTANDER Multiple languages Virology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/28078