Park, Se Eun, Pak, Gi Deok, Aaby, Peter ORCID: 0000-0001-8331-1389, Adu-Sarkodie, Yaw, Ali, Mohammad, Aseffa, Abraham ORCID: 0000-0002-8028-1150, Biggs, Holly M., Bjerregaard-Andersen, Morten, Breiman, Robert F., Crump, John A. ORCID: 0000-0002-4529-102X, Cruz Espinoza, Ligia Maria, Eltayeb, Muna Ahmed, Gasmelseed, Nagla, Hertz, Julian T., Im, Justin, Jaeger, Anna, Parfait Kabore, Leon, von Kalckreuth, Vera, Keddy, Karen H., Konings, Frank, Krumkamp, Ralf, MacLennan, Calman A., Meyer, Christian G., Montgomery, Joel M., Ahmet Niang, Aissatou, Nichols, Chelsea, Olack, Beatrice, Panzner, Ursula, Park, Jin Kyung, Rabezanahary, Henintsoa, Rakotozandrindrainy, Raphael, Sampo, Emmanuel, Sarpong, Nimako, Schuett-Gerowitt, Heidi, Sooka, Arvinda, Soura, Abdramane Bassiahi, Sow, Amy Gassama, Tall, Adama, Teferi, Mekonnen, Yeshitela, Biruk, May, Juegen, Wierzba, Thomas F., Clemens, John D., Baker, Stephen and Marks, Florian ORCID: 0000-0002-6043-7170 (2016). The Relationship Between Invasive Nontyphoidal Disease, Other Bacterial Bloodstream Infections, and Malaria in Sub-Saharan Africa. Clin. Infect. Dis., 62. S. S23 - 9. CARY: OXFORD UNIV PRESS INC. ISSN 1537-6591

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Abstract

Methods.aEuro integral Febrile patients received a blood culture and a malaria test. Isolated bacteria underwent antimicrobial susceptibility testing, and the association between iNTS disease and malaria was assessed. Results.aEuro integral A positive correlation between frequency proportions of malaria and iNTS was observed (P = .01; r = 0.70). Areas with higher burden of malaria exhibited higher odds of iNTS disease compared to other bacterial infections (odds ratio [OR], 4.89; 95% CI, 1.61-14.90; P = .005) than areas with lower malaria burden. Malaria parasite positivity was associated with iNTS disease (OR, 2.44; P = .031) and gram-positive bacteremias, particularly Staphylococcus aureus, exhibited a high proportion of coinfection with Plasmodium malaria. Salmonella Typhimurium and Salmonella Enteritidis were the predominant NTS serovars (53/73; 73%). Both moderate (OR, 6.05; P = .0001) and severe (OR, 14.62; P < .0001) anemia were associated with iNTS disease. Conclusions.aEuro integral A positive correlation between iNTS disease and malaria endemicity, and the association between Plasmodium parasite positivity and iNTS disease across sub-Saharan Africa, indicates the necessity to consider iNTS as a major cause of febrile illness in malaria-holoendemic areas. Prevention of iNTS disease through iNTS vaccines for areas of high malaria endemicity, targeting high-risk groups for Plasmodium parasitic infection, should be considered.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Park, Se EunUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pak, Gi DeokUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aaby, PeterUNSPECIFIEDorcid.org/0000-0001-8331-1389UNSPECIFIED
Adu-Sarkodie, YawUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ali, MohammadUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aseffa, AbrahamUNSPECIFIEDorcid.org/0000-0002-8028-1150UNSPECIFIED
Biggs, Holly M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bjerregaard-Andersen, MortenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Breiman, Robert F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Crump, John A.UNSPECIFIEDorcid.org/0000-0002-4529-102XUNSPECIFIED
Cruz Espinoza, Ligia MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eltayeb, Muna AhmedUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gasmelseed, NaglaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hertz, Julian T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Im, JustinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jaeger, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Parfait Kabore, LeonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
von Kalckreuth, VeraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Keddy, Karen H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Konings, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krumkamp, RalfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
MacLennan, Calman A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meyer, Christian G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Montgomery, Joel M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ahmet Niang, AissatouUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nichols, ChelseaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Olack, BeatriceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Panzner, UrsulaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Park, Jin KyungUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rabezanahary, HenintsoaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rakotozandrindrainy, RaphaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sampo, EmmanuelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sarpong, NimakoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schuett-Gerowitt, HeidiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sooka, ArvindaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Soura, Abdramane BassiahiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sow, Amy GassamaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tall, AdamaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Teferi, MekonnenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yeshitela, BirukUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
May, JuegenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wierzba, Thomas F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Clemens, John D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baker, StephenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marks, FlorianUNSPECIFIEDorcid.org/0000-0002-6043-7170UNSPECIFIED
URN: urn:nbn:de:hbz:38-281366
DOI: 10.1093/cid/civ893
Journal or Publication Title: Clin. Infect. Dis.
Volume: 62
Page Range: S. S23 - 9
Date: 2016
Publisher: OXFORD UNIV PRESS INC
Place of Publication: CARY
ISSN: 1537-6591
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
PLASMODIUM-FALCIPARUM MALARIA; CHRONIC GRANULOMATOUS-DISEASE; SALMONELLA DISEASE; MALAWIAN CHILDREN; BACTEREMIA; SUSCEPTIBILITY; COINFECTION; PREVALENCE; RESISTANCE; DIAGNOSISMultiple languages
Immunology; Infectious Diseases; MicrobiologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/28136

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