Universität zu Köln

Lindgren, Patricia Komp, Higgins, Paul G. ORCID: 0000-0001-8677-9454, Seifert, Harald and Cars, Otto (2016). Prevalence of hypermutators among clinical Acinetobacter baumannii isolates. J. Antimicrob. Chemother., 71 (3). S. 661 - 666. OXFORD: OXFORD UNIV PRESS. ISSN 1460-2091

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Abstract

The objectives of this study were to study the presence of mutators in a set of Acinetobacter baumannii isolates and to explore whether there is a correlation between mutation rates and antibiotic resistance. The variation in mutation rate was evaluated for 237 clinical A. baumannii isolates by determining the frequency of their mutation to rifampicin resistance. For each isolate, the antibiotic resistance profile was determined by disc diffusion and/or Etest. Isolates were divided into susceptible, resistant and MDR groups according to their resistance to five groups of different antibiotics. A comparison between differences in mutation frequency (f) and strain-specific factors was performed. Of the 237 isolates 32%, 18% and 50% were classified as susceptible, resistant and MDR, respectively. The f of rifampicin resistance varied between 2.2aEuroSxaEuroS10(-10) and 1.2aEuroSxaEuroS10(-6). Of the strains under investigation, 16% had an a parts per thousand yen2.5- to 166-fold higher f. The presence of mutators (definition a parts per thousand yen2.5-fold increase in f compared with ATCC 19606) in the MDR group (22%) was significantly higher (PaEuroS < aEuroS0.05) than that in the susceptible and resistant groups (11% and 7%, respectively). Furthermore, f was significantly higher in the MDR group compared with that in the susceptible and resistant groups. The facts that 26 of 37 mutator isolates (70%) in the population were MDR and that there was a significantly higher general f in isolates exhibiting an MDR profile suggest that hypermutability can be of advantage for the organism in a selective environment with extensive exposure to antimicrobials.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Lindgren, Patricia Komp UNSPECIFIED UNSPECIFIED UNSPECIFIED Higgins, Paul G. UNSPECIFIED orcid.org/0000-0001-8677-9454 UNSPECIFIED Seifert, Harald UNSPECIFIED UNSPECIFIED UNSPECIFIED Cars, Otto UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-283770
DOI:	10.1093/jac/dkv378
Journal or Publication Title:	J. Antimicrob. Chemother.
Volume:	71
Number:	3
Page Range:	S. 661 - 666
Date:	2016
Publisher:	OXFORD UNIV PRESS
Place of Publication:	OXFORD
ISSN:	1460-2091
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language POLYMORPHIC MUTATION FREQUENCIES; ESCHERICHIA-COLI; FLUOROQUINOLONE RESISTANCE; MOLECULAR EPIDEMIOLOGY; ANTIBIOTIC-RESISTANCE; WEAK MUTATORS; EVOLUTION; BACTERIA; EMERGENCE; GENE Multiple languages Infectious Diseases; Microbiology; Pharmacology & Pharmacy Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/28377