Universität zu Köln

Ploenes, Till, Engel-Riedel, Walburga, Stoelben, Erich, Limmroth, Christina, Schildgen, Oliver ORCID: 0000-0003-4297-9627 and Schildgen, Verena (2016). Molecular Pathology and Personalized Medicine: The Dawn of a New Era in Companion Diagnostics-Practical Considerations about Companion Diagnostics for Non-Small-Cell-Lung-Cancer. J. Pers. Med., 6 (1). BASEL: MDPI. ISSN 2075-4426

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Abstract

Companion diagnostics (CDx) have become a major tool in molecular pathology and assist in therapy decisions in an increasing number of various cancers. Particularly, the developments in lung cancer have been most impressing in the last decade and consequently lung cancer mutation testing and molecular profiling has become a major business of diagnostic laboratories. However, it has become difficult to decide which biomarkers are currently relevant for therapy decisions, as many of the new biomarkers are not yet approved as therapy targets, remain in the status of clinical studies, or still have not left the experimental phase. The current review is focussed on those markers that do have current therapy implications, practical implications arising from the respective companion diagnostics, and thus is focused on daily practice.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ploenes, Till UNSPECIFIED UNSPECIFIED UNSPECIFIED Engel-Riedel, Walburga UNSPECIFIED UNSPECIFIED UNSPECIFIED Stoelben, Erich UNSPECIFIED UNSPECIFIED UNSPECIFIED Limmroth, Christina UNSPECIFIED UNSPECIFIED UNSPECIFIED Schildgen, Oliver UNSPECIFIED orcid.org/0000-0003-4297-9627 UNSPECIFIED Schildgen, Verena UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-283864
DOI:	10.3390/jpm6010003
Journal or Publication Title:	J. Pers. Med.
Volume:	6
Number:	1
Date:	2016
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2075-4426
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CELL LUNG-CANCER; GENERATION SEQUENCING NGS; EML4-ALK FUSION GENES; REAL-TIME PCR; EGFR MUTATIONS; KRAS MUTATIONS; CYTOLOGICAL SPECIMENS; RESISTANCE MUTATIONS; ACQUIRED-RESISTANCE; TARGETED THERAPIES Multiple languages Health Care Sciences & Services; Medicine, General & Internal Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/28386