Universität zu Köln

Kuehn, Anne B., Feis, Delia-Lisa, Schilbach, Leonhard ORCID: 0000-0001-5547-8309, Kracht, Lutz, Hess, Martin E., Mauer, Jan ORCID: 0000-0002-0189-5876, Bruening, Jens C. and Tittgemeyer, Marc ORCID: 0000-0001-5072-2149 (2016). FTO gene variant modulates the neural correlates of visual food perception. Neuroimage, 128. S. 21 - 32. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE. ISSN 1095-9572

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Abstract

Variations in the fat mass and obesity associated (FTO) gene are currently the strongest knowngenetic factor predisposing humans to non-monogenic obesity. Recent experiments have linked these variants to a broad spectrum of behavioural alterations, including food choice and substance abuse. Yet, the underlying neurobiological mechanisms by which these genetic variations influence body weight remain elusive. Here, we explore the brain structural substrate of the obesity-predisposing rs9939609 T/A variant of the FTO gene in non-obese subjects bymeans ofmultivariate classification and use fMRI to investigate genotype-specific differences in neural food-cue reactivity by analysing correlates of a visual food perception task. Our findings demonstrate that MRI-derived measures of morphology along middle and posterior fusiform gyrus (FFG) are highly predictive for FTO at-risk allele carriers, who also show enhanced neural responses elicited by food cues in the same posterior FFG area. In brief, these findings provide first-time evidence for FTO-specific differences in both brain structure and function already in non-obese individuals, thereby contributing to amechanistic understanding of why FTO is a predisposing factor for obesity. (C) 2015 Elsevier Inc. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kuehn, Anne B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Feis, Delia-Lisa UNSPECIFIED UNSPECIFIED UNSPECIFIED Schilbach, Leonhard UNSPECIFIED orcid.org/0000-0001-5547-8309 UNSPECIFIED Kracht, Lutz UNSPECIFIED UNSPECIFIED UNSPECIFIED Hess, Martin E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mauer, Jan UNSPECIFIED orcid.org/0000-0002-0189-5876 UNSPECIFIED Bruening, Jens C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Tittgemeyer, Marc UNSPECIFIED orcid.org/0000-0001-5072-2149 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-283998
DOI:	10.1016/j.neuroimage.2015.12.049
Journal or Publication Title:	Neuroimage
Volume:	128
Page Range:	S. 21 - 32
Date:	2016
Publisher:	ACADEMIC PRESS INC ELSEVIER SCIENCE
Place of Publication:	SAN DIEGO
ISSN:	1095-9572
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HIGH-CALORIE FOODS; DIFFUSION MRI DATA; BODY-MASS INDEX; HUMAN BRAIN; WEIGHT-GAIN; FUNCTIONAL NEUROANATOMY; CORTICAL CONNECTIONS; FACIAL RECOGNITION; FUSIFORM GYRUS; DRUG-ADDICTION Multiple languages Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/28399