Backes, Heiko, Walberer, Maureen, Ladwig, Anne, Rueger, Maria A., Neumaier, Bernd ORCID: 0000-0001-5425-3116, Endepols, Heike ORCID: 0000-0002-6166-4818, Hoehn, Mathias, Fink, Gereon R. ORCID: 0000-0002-8230-1856, Schroeter, Michael and Graf, Rudolf (2016). Glucose consumption of inflammatory cells masks metabolic deficits in the brain. Neuroimage, 128. S. 54 - 63. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE. ISSN 1095-9572

Full text not available from this repository.

Abstract

Inflammatory cells such as microglia need energy to exert their functions and to maintain their cellular integrity and membrane potential. Subsequent to cerebral ischemia, inflammatory cells infiltrate tissue with limited blood flow where neurons and astrocytes died due to insufficient supply with oxygen and glucose. Using dual tracer positron emission tomography (PET), we found that concomitant with the presence of inflammatory cells, transport and consumption of glucose increased up to normal levels but returned to pathological levels as soon as inflammatory cells disappeared. Thus, inflammatory cells established sufficient glucose supply to satisfy their energy demands even in regions with insufficient supply for neurons and astrocytes to survive. Our data suggest that neurons and astrocytes died from oxygen deficiency and inflammatory cells metabolized glucose non-oxidatively in regions with residual availability. As a consequence, glucose metabolism of inflammatory cells can mask metabolic deficits in neurodegenerative diseases. We further found that the PET tracer did not bind to inflammatory cells in severely hypoperfused regions and thus only a part of the inflammation was detected. We conclude that glucose consumption of inflammatory cells should be taken into account when analyzing disease-related alterations of local cerebral metabolism. (C) 2016 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Backes, HeikoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Walberer, MaureenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ladwig, AnneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rueger, Maria A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Neumaier, BerndUNSPECIFIEDorcid.org/0000-0001-5425-3116UNSPECIFIED
Endepols, HeikeUNSPECIFIEDorcid.org/0000-0002-6166-4818UNSPECIFIED
Hoehn, MathiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fink, Gereon R.UNSPECIFIEDorcid.org/0000-0002-8230-1856UNSPECIFIED
Schroeter, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Graf, RudolfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-284000
DOI: 10.1016/j.neuroimage.2015.12.044
Journal or Publication Title: Neuroimage
Volume: 128
Page Range: S. 54 - 63
Date: 2016
Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE
Place of Publication: SAN DIEGO
ISSN: 1095-9572
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
MICROGLIAL ACTIVATION; REFERENCE TISSUE; PET; STROKE; QUANTIFICATION; ISCHEMIA; RECEPTOR; DISEASE; MODELMultiple languages
Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical ImagingMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/28400

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item