Universität zu Köln

Schulz, Jan-Niklas ORCID: 0000-0001-9286-206X, Nuechel, Julian, Niehoff, Anja, Bloch, Wilhelm, Schoenborn, Katrin, Hayashi, Shujiro, Kamper, Matthias, Brinckmann, Juergen, Plomann, Markus, Paulsson, Mats, Krieg, Thomas, Zaucke, Frank and Eckes, Beate (2016). COMP-assisted collagen secretion - a novel intracellular function required for fibrosis. J. Cell Sci., 129 (4). S. 706 - 717. CAMBRIDGE: COMPANY OF BIOLOGISTS LTD. ISSN 1477-9137

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Abstract

Cartilage oligomeric matrix protein (COMP) is an abundant component in the extracellular matrix (ECM) of load-bearing tissues such as tendons and cartilage. It provides adaptor functions by bridging different ECM structures. We have previously shown that COMP is also a constitutive component of healthy human skin and is strongly induced in fibrosis. It binds directly and with high affinity to collagen I and to collagen XII that decorates the surface of collagen I fibrils. We demonstrate here that lack of COMP-collagen interaction in the extracellular space leads to changes in collagen fibril morphology and density, resulting in altered skin biomechanical properties. Surprisingly, COMP also fulfills an important intracellular function in assisting efficient secretion of collagens, which were retained in the endoplasmic reticulum of COMP-null fibroblasts. Accordingly, COMP-null mice showed severely attenuated fibrotic responses in skin. Collagen secretion was fully restored by introducing wild-type COMP. Hence, our work unravels a new, non-structural and intracellular function of the ECM protein COMP in controlling collagen secretion.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schulz, Jan-Niklas UNSPECIFIED orcid.org/0000-0001-9286-206X UNSPECIFIED Nuechel, Julian UNSPECIFIED UNSPECIFIED UNSPECIFIED Niehoff, Anja UNSPECIFIED UNSPECIFIED UNSPECIFIED Bloch, Wilhelm UNSPECIFIED UNSPECIFIED UNSPECIFIED Schoenborn, Katrin UNSPECIFIED UNSPECIFIED UNSPECIFIED Hayashi, Shujiro UNSPECIFIED UNSPECIFIED UNSPECIFIED Kamper, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Brinckmann, Juergen UNSPECIFIED UNSPECIFIED UNSPECIFIED Plomann, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Paulsson, Mats UNSPECIFIED UNSPECIFIED UNSPECIFIED Krieg, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Zaucke, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Eckes, Beate UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-284597
DOI:	10.1242/jcs.180216
Journal or Publication Title:	J. Cell Sci.
Volume:	129
Number:	4
Page Range:	S. 706 - 717
Date:	2016
Publisher:	COMPANY OF BIOLOGISTS LTD
Place of Publication:	CAMBRIDGE
ISSN:	1477-9137
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language OLIGOMERIC MATRIX PROTEIN; MULTIPLE EPIPHYSEAL DYSPLASIA; ER STRESS-RESPONSE; EXTRACELLULAR-MATRIX; SYSTEMIC-SCLEROSIS; GRANULATION-TISSUE; CAUSE PSEUDOACHONDROPLASIA; ELECTRON-MICROSCOPY; CALCIUM-BINDING; CARTILAGE Multiple languages Cell Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/28459