Riehl, Lara M., Schulte, Johannes H., Mulaw, Medhanie A. ORCID: 0000-0002-2501-6952, Dahlhaus, Meike, Fischer, Matthias, Schramm, Alexander ORCID: 0000-0001-7670-7529, Eggert, Angelika, Debatin, Klaus-Michael ORCID: 0000-0002-8397-1886 and Beltinger, Christian (2016). The mitochondrial genetic landscape in neuroblastoma from tumor initiation to relapse. Oncotarget, 7 (6). S. 6620 - 6626. ORCHARD PARK: IMPACT JOURNALS LLC. ISSN 1949-2553

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Abstract

Little is known about changes within the mitochondrial (mt) genome during tumor progression in general and during initiation and progression of neuroblastoma (NB) in particular. Whole exome sequencing of corresponding healthy tissue, primary tumor and relapsed tumor from 16 patients with NB revealed that most NB harbor tumor-specific mitochondrial variants. In relapsed tumors, the status of mt variants changed in parallel to the status of nuclear variants, as shown by increased number and spatio-temporal differences of tumor-specific variants, and by a concomitant decrease of germline variants. As mt variants are present in most NB patients, change during relapse and have a higher copy number compared to nuclear variants, they represent a promising new source of biomarkers for monitoring and phylogenetic analysis of NB.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Riehl, Lara M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schulte, Johannes H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mulaw, Medhanie A.UNSPECIFIEDorcid.org/0000-0002-2501-6952UNSPECIFIED
Dahlhaus, MeikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fischer, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schramm, AlexanderUNSPECIFIEDorcid.org/0000-0001-7670-7529UNSPECIFIED
Eggert, AngelikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Debatin, Klaus-MichaelUNSPECIFIEDorcid.org/0000-0002-8397-1886UNSPECIFIED
Beltinger, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-284695
DOI: 10.18632/oncotarget.6776
Journal or Publication Title: Oncotarget
Volume: 7
Number: 6
Page Range: S. 6620 - 6626
Date: 2016
Publisher: IMPACT JOURNALS LLC
Place of Publication: ORCHARD PARK
ISSN: 1949-2553
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
Oncology; Cell BiologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/28469

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