Heuser, Sandra, Hufbauer, Martin, Marx, Benjamin, Tok, Ali, Majewski, Slawomir, Pfister, Herbert and Akguel, Baki (2016). The levels of epithelial anchor proteins beta-catenin and zona occludens-1 are altered by E7 of human papillomaviruses 5 and 8. J. Gen. Virol., 97. S. 463 - 473. LONDON: MICROBIOLOGY SOC. ISSN 1465-2099

Full text not available from this repository.

Abstract

Infection with viruses of the genus Betapapillomavirus, beta-human papillomaviruses (beta-HPV), is implicated in the development of non-melanoma skin cancer. This was first evidenced for HPV5 and HPV8 in patients with the skin disease epidermodysplasia verruciformis (EV). The relocalization of the junctional bridging proteins beta-catenin and zona occludens-1 (ZO-1) from the adherens and tight junctions are common processes of the epithelial-mesenchymal transition (EMT) associated with tumour invasion. Here, we report that beta-catenin and ZO-1 are strongly upregulated by the E7 oncoproteins of HPV5 and HPV8 in keratinocytes grown in organotypic skin cultures. Although the membrane-tethered form of beta-catenin was elevated, no signs of beta-catenin activity within the canonical Wnt signalling pathway could be detected. The upregulation of beta-catenin and ZO-1 could also be confirmed in the skin of HPV8 transgenic mice as well as in cutaneous squamous cell carcinomas of EV patients. These data provide the first evidence that beta-catenin and ZO-1 are direct targets of E7 of the oncogenic beta-HPV types 5 and 8. The ability to deregulate these epithelial junction proteins may contribute to the oncogenic potential of these viruses in human skin.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Heuser, SandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hufbauer, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marx, BenjaminUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tok, AliUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Majewski, SlawomirUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pfister, HerbertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Akguel, BakiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-285117
DOI: 10.1099/jgv.0.000363
Journal or Publication Title: J. Gen. Virol.
Volume: 97
Page Range: S. 463 - 473
Date: 2016
Publisher: MICROBIOLOGY SOC
Place of Publication: LONDON
ISSN: 1465-2099
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
TIGHT JUNCTION PROTEINS; EPIDERMODYSPLASIA-VERRUCIFORMIS; EARLY GENES; SKIN; KERATINOCYTES; INVASION; CANCER; ZO-1; HPV; DIFFERENTIATIONMultiple languages
Biotechnology & Applied Microbiology; VirologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/28511

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item