Universität zu Köln

Brumbarova, Tzvetina ORCID: 0000-0002-3104-6795, Ivanov, Rumen ORCID: 0000-0001-7909-4123 and Bauer, Petra (2016). Regulation of ZAT12 protein stability: The role of hydrogen peroxide. Plant Signal. Behav., 11 (2). PHILADELPHIA: TAYLOR & FRANCIS INC. ISSN 1559-2324

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Abstract

Signaling mediated by reactive oxygen species (ROS) has emerged as a key component of plants' responses to environmental stress. The ROS-regulated transcription factor ZAT12 was revealed as a negative regulator of iron (Fe) deficiency responses through its direct interaction with the bHLH protein FIT. In the epidermis of the early root differentiation zone, ZAT12 stability depended on the presence of the ZAT12 EAR motif. It was concluded that ZAT12 may be the target of 2 alternative degradation pathways. Here, we present a model aiming to explain the regulatory mechanisms by which ZAT12 could be targeted for degradation and to predict the types of potential regulators involved. In addition to an E3 ubiquitin ligase, we predict 2 critical regulatory factors, namely a protein interacting with the ZAT12 EAR motif and a ROS-responsive regulatory protein.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Brumbarova, Tzvetina UNSPECIFIED orcid.org/0000-0002-3104-6795 UNSPECIFIED Ivanov, Rumen UNSPECIFIED orcid.org/0000-0001-7909-4123 UNSPECIFIED Bauer, Petra UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-285192
DOI:	10.1080/15592324.2015.1137408
Journal or Publication Title:	Plant Signal. Behav.
Volume:	11
Number:	2
Date:	2016
Publisher:	TAYLOR & FRANCIS INC
Place of Publication:	PHILADELPHIA
ISSN:	1559-2324
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CYTOSOLIC ASCORBATE PEROXIDASE-1; REACTIVE OXYGEN; IRON; STRESS; ROS Multiple languages Biochemistry & Molecular Biology; Plant Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/28519