Universität zu Köln

Rubbert-Roth, A., Zander, T., Kneitz, C., Baerwald, C., Wirtz, H. and Witt, C. (2016). Lung cancer and rheumatoid arthritis. An interdisciplinary challenge. Z. Rheumatol., 75 (1). S. 47 - 54. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1435-1250

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Abstract

Lung cancer is a frequently occurring disease, particularly in the elderly; however, within the last 10 years the pharmaceutical treatment of lung cancer has been significantly improved. Due to a better understanding of the pathophysiological events and the identification of molecular subgroups of lung tumors, new therapeutic drugs have been developed that significantly prolong survival of patients with the respective molecular pattern. In particular immunotherapeutic agents, such as programmed death-ligand 1 (PD-L1) and programmed death 1 (PD1) antibodies have shown promising clinical results in a subgroup of lung cancer patients. Due to the high incidence of both lung cancer and rheumatic diseases they often occur together, which necessitates an interdisciplinary management. The success of improved therapy of lung cancer has led to a greater focus on the treatment of comorbidities; however, interventions into the immune system by immune checkpoint inhibitors can lead to new challenges when an autoimmune disease is simultaneously present. The possibility of an effective screening for lung cancer in the future also presents the prospect of an improvement in mortality, which raises the question of the optimal monitoring of patients with rheumatoid arthritis (RA) under immunosuppressive therapy. The aim of this review is to discuss the interaction between lung cancer and RA with respect to the currently available data.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rubbert-Roth, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zander, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kneitz, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Baerwald, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wirtz, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Witt, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-285301
DOI:	10.1007/s00393-016-0043-0
Journal or Publication Title:	Z. Rheumatol.
Volume:	75
Number:	1
Page Range:	S. 47 - 54
Date:	2016
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1435-1250
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LONG-TERM SAFETY; BIOLOGICS REGISTER; RISK; THERAPY; CHEMOTHERAPY; GEFITINIB; ERLOTINIB; DISEASE; GENE Multiple languages Rheumatology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/28530