Universität zu Köln

Zoellner, Frank G., Konstandin, Simon, Lommen, Jonathan, Budjan, Johannes, Schoenberg, Stefan O., Schad, Lothar R. and Haneder, Stefan (2016). Quantitative sodium MRI of kidney. NMR Biomed., 29 (2). S. 197 - 206. HOBOKEN: WILEY. ISSN 1099-1492

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Abstract

One of the main tasks of the human kidneys is to maintain the homeostasis of the body's fluid and electrolyte balance by filtration of the plasma and excretion of the end products. Herein, the regulation of extracellular sodium in the kidney is of particular importance. Sodium MRI (Na-23 MRI) allows for the absolute quantification of the tissue sodium concentration (TSC) and thereby provides a direct link between TSC and tissue viability. Renal Na-23 MRI can provide new insights into physiological tissue function and viability thought to differ from the information obtained by standard H-1 MRI. Sodium imaging has the potential to become an independent surrogate biomarker not only for renal imaging, but also for oncology indications. However, this technique is now on the threshold of clinical implementation. Numerous, initial pre-clinical and clinical studies have already outlined the potential of this technique; however, future studies need to be extended to larger patient groups to show the diagnostic outcome. In conclusion, Na-23 MRI is seen as a powerful technique with the option to establish a non-invasive renal biomarker for tissue viability, but is still a long way from real clinical implementation. Copyright (c) 2015 John Wiley & Sons, Ltd.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Zoellner, Frank G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Konstandin, Simon UNSPECIFIED UNSPECIFIED UNSPECIFIED Lommen, Jonathan UNSPECIFIED UNSPECIFIED UNSPECIFIED Budjan, Johannes UNSPECIFIED UNSPECIFIED UNSPECIFIED Schoenberg, Stefan O. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schad, Lothar R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Haneder, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-285932
DOI:	10.1002/nbm.3274
Journal or Publication Title:	NMR Biomed.
Volume:	29
Number:	2
Page Range:	S. 197 - 206
Date:	2016
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1099-1492
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ACUTE TUBULAR-NECROSIS; TISSUE; QUANTIFICATION; RESONATOR; METABOLITES; EXCITATION; NA-23-MRI; ACCURATE; DESIGN; SYSTEM Multiple languages Biophysics; Radiology, Nuclear Medicine & Medical Imaging; Spectroscopy Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/28593