Universität zu Köln

Luetkens, Julian A., Homsi, Rami, Sprinkart, Alois M., Doerner, Jonas, Dabir, Darius, Kuetting, Daniel L., Block, Wolfgang, Andrie, Rene, Stehning, Christian, Fimmers, Rolf, Gieseke, Juergen, Thomas, Daniel K., Schild, Hans H. and Naehle, Claas P. (2016). Incremental value of quantitative CMR including parametric mapping for the diagnosis of acute myocarditis. Eur. Heart J.-Cardiovasc. Imaging, 17 (2). S. 154 - 162. OXFORD: OXFORD UNIV PRESS. ISSN 2047-2412

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Abstract

Aim Cardiac magnetic resonance (CMR) can visualize inflammatory tissue changes in acute myocarditis. Several quantitative image-derived parameters have been described to enhance the diagnostic value of CMR, but no direct comparison of these techniques is available. Methods and results A total of 34 patients with suspected acute myocarditis and 50 control subjects underwent CMR. CMR protocol included quantitative assessment of T1 relaxation times using modified Look-Locker inversion recovery (MOLLI) and shortened MOLLI (ShMOLLI) acquisition schemes, extracellular volume fraction (ECV), T2 relaxation times, and longitudinal strain. Established Lake-Louise criteria (LLC) consisting of T2-weighted signal intensity ratio (T2-ratio), early gadolinium enhancement ratio (EGEr), and late gadolinium enhancement (LGE) were assessed. Receiver operating characteristics analysiswas performed to compare diagnostic performance. Areas under the curve of native T1 (MOLLI: 0.95; ShMOLLI: 0.92) and T2 relaxation times (0.92) were higher compared with those of the other CMR parameters (T2-ratio: 0.71, EGEr: 0.71, LGE: 0.87, LLC: 0.90, ECV MOLLI: 0.77, ECV ShMOLLI: 0.80, longitudinal strain: 0.83). Combined with LGE, each native mapping technique outperformed the diagnostic performance of LLC (P, 0.01, respectively). A combination of native parameters (T1, T2, and longitudinal strain) significantly increased the diagnostic performance of CMR compared with LLC without need of contrast media application (0.99 vs. 0.90; P = 0.008). Conclusion In patients suspected of having acute myocarditis, diagnostic performance of CMR can be improved by implementation of quantitative CMR parameters. Especially, native mapping techniques have the potential to replace current LLC.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Luetkens, Julian A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Homsi, Rami UNSPECIFIED UNSPECIFIED UNSPECIFIED Sprinkart, Alois M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Doerner, Jonas UNSPECIFIED UNSPECIFIED UNSPECIFIED Dabir, Darius UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuetting, Daniel L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Block, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Andrie, Rene UNSPECIFIED UNSPECIFIED UNSPECIFIED Stehning, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Fimmers, Rolf UNSPECIFIED UNSPECIFIED UNSPECIFIED Gieseke, Juergen UNSPECIFIED UNSPECIFIED UNSPECIFIED Thomas, Daniel K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schild, Hans H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Naehle, Claas P. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-286214
DOI:	10.1093/ehjci/jev246
Journal or Publication Title:	Eur. Heart J.-Cardiovasc. Imaging
Volume:	17
Number:	2
Page Range:	S. 154 - 162
Date:	2016
Publisher:	OXFORD UNIV PRESS
Place of Publication:	OXFORD
ISSN:	2047-2412
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CARDIOVASCULAR MAGNETIC-RESONANCE; ENDOMYOCARDIAL BIOPSY; CARDIAC MR; HEART; QUANTIFICATION; ASSOCIATION; VALIDATION; CARDIOLOGY; STATEMENT; ACCURACY Multiple languages Cardiac & Cardiovascular Systems; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/28621