Universität zu Köln

Dovern, Anna, Fink, Gereon R. ORCID: 0000-0002-8230-1856, Timpert, David C., Saliger, Jochen, Karbe, Hans, Weiss, Peter H. ORCID: 0000-0002-5230-9080 and Koch, Iring (2016). Timing Matters? Learning of Complex Spatiotemporal Sequences in Left-hemisphere Stroke Patients. J. Cogn. Neurosci., 28 (2). S. 223 - 237. CAMBRIDGE: MIT PRESS. ISSN 1530-8898

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Abstract

During rehabilitation after stroke motor sequence learning is of particular importance because considerable effort is devoted to (re)acquiring lost motor skills. Previous studies suggest that implicit motor sequence learning is preserved in stroke patients but were restricted to the spatial dimension, although the timing of single action components is as important as their spatial order. As the left parietal cortex is known to play a critical role in implicit timing and spatiotemporal integration, in this study we applied an adapted version of the SRT task designed to assess both spatial (different stimulus locations) and temporal (different response-stimulus intervals) aspects of motor learning to 24 right-handed patients with a single left-hemisphere (LH) stroke and 24 age-matched healthy controls. Implicit retrieval of sequence knowledge was tested both at Day 1 and after 24 hr (Day 2). Additionally, voxel-based lesion symptom mapping was used to investigate the neurobiological substrates of the behavioral effects. Although LH stroke patients showed a combined spatiotemporal learning effect that was comparable to that observed in controls, LH stroke patients did not show learning effects for the learning probes in which only one type of sequence information was maintained whereas the other one was randomized. Particularly on Day 2, patients showed significantly smaller learning scores for these two learning probes than controls. Voxel-based lesion symptom mapping analyses revealed for all learning probes that diminished learning scores on Day 2 were associated with lesions of the striatum. This might be attributed to its role in motor chunking and offline consolidation as group differences occurred on Day 2 only. The current results suggest that LH stroke patients rely on multimodal information (here: temporal and spatial information) when retrieving motor sequence knowledge and are very sensitive to any disruption of the learnt sequence information as they seem to build very rigid chunks preventing them from forming independent spatial and temporal sequence representations.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Dovern, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Timpert, David C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Saliger, Jochen UNSPECIFIED UNSPECIFIED UNSPECIFIED Karbe, Hans UNSPECIFIED UNSPECIFIED UNSPECIFIED Weiss, Peter H. UNSPECIFIED orcid.org/0000-0002-5230-9080 UNSPECIFIED Koch, Iring UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-286424
DOI:	10.1162/jocn_a_00890
Journal or Publication Title:	J. Cogn. Neurosci.
Volume:	28
Number:	2
Page Range:	S. 223 - 237
Date:	2016
Publisher:	MIT PRESS
Place of Publication:	CAMBRIDGE
ISSN:	1530-8898
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LEFT PARIETAL CORTEX; BASAL GANGLIA; MOTOR SKILL; TIME; ATTENTION; CONSOLIDATION; STRIATUM; INTEGRATION; MECHANISMS; COMPONENTS Multiple languages Neurosciences; Psychology, Experimental Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/28642