Benoit, Joshua B., Adelman, Zach N., Reinhardt, Klaus, Dolan, Amanda, Poelchau, Monica ORCID: 0000-0002-4584-6056, Jennings, Emily C., Szuter, Elise M., Hagan, Richard W., Gujar, Hemant, Shukla, Jayendra Nath, Zhu, Fang, Mohan, M., Nelson, David R., Rosendale, Andrew J., Derst, Christian, Resnik, Valentina, Wernig, Sebastian, Menegazzi, Pamela ORCID: 0000-0001-5232-1920, Wegener, Christian ORCID: 0000-0003-4481-3567, Peschel, Nicolai, Hendershot, Jacob M., Blenau, Wolfgang ORCID: 0000-0002-6874-4730, Predel, Reinhard, Johnston, Paul R., Ioannidis, Panagiotis ORCID: 0000-0003-0939-6745, Waterhouse, Robert M., Nauen, Ralf ORCID: 0000-0002-7525-8589, Schorn, Corinna, Ott, Mark-Christoph, Maiwald, Frank, Johnston, J. Spencer, Gondhalekar, Ameya D., Scharf, Michael E., Peterson, Brittany F., Raje, Kapil R., Hottel, Benjamin A., Armisen, David, Crumiere, Antonin Jean Johan, Refki, Peter Nagui, Santos, Maria Emilia, Sghaier, Essia, Viala, Severine, Khila, Abderrahman ORCID: 0000-0003-0908-483X, Ahn, Seung-Joon ORCID: 0000-0002-5980-106X, Childers, Christopher, Lee, Chien-Yueh, Lin, Han, Hughes, Daniel S. T., Duncan, Elizabeth J., Murali, Shwetha C., Qu, Jiaxin, Dugan, Shannon, Lee, Sandra L., Chao, Hsu, Dinh, Huyen, Han, Yi, Doddapaneni, Harshavardhan, Worley, Kim C., Muzny, Donna M., Wheeler, David ORCID: 0000-0001-5538-8119, Panfilio, Kristen A., Jentzsch, Iris M. Vargas, Vargo, Edward L., Booth, Warren, Friedrich, Markus, Weirauch, Matthew T., Anderson, Michelle A. E., Jones, Jeffery W., Mittapalli, Omprakash, Zhao, Chaoyang, Zhou, Jing-Jiang, Evans, Jay D., Attardo, Geoffrey M., Robertson, Hugh M., Zdobnov, Evgeny M., Ribeiro, Jose M. C., Gibbs, Richard A., Werren, John H., Palli, Subba R., Schal, Coby ORCID: 0000-0001-7195-6358 and Richards, Stephen ORCID: 0000-0001-8959-5466 (2016). Unique features of a global human ectoparasite identified through sequencing of the bed bug genome. Nat. Commun., 7. LONDON: NATURE PUBLISHING GROUP. ISSN 2041-1723

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Abstract

The bed bug, Cimex lectularius, has re-established itself as a ubiquitous human ectoparasite throughout much of the world during the past two decades. This global resurgence is likely linked to increased international travel and commerce in addition to widespread insecticide resistance. Analyses of the C. lectularius sequenced genome (650Mb) and 14,220 predicted protein-coding genes provide a comprehensive representation of genes that are linked to traumatic insemination, a reduced chemosensory repertoire of genes related to obligate hematophagy, host-symbiont interactions, and several mechanisms of insecticide resistance. In addition, we document the presence of multiple putative lateral gene transfer events. Genome sequencing and annotation establish a solid foundation for future research on mechanisms of insecticide resistance, human-bed bug and symbiont-bed bug associations, and unique features of bed bug biology that contribute to the unprecedented success of C. lectularius as a human ectoparasite.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Benoit, Joshua B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Adelman, Zach N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reinhardt, KlausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dolan, AmandaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Poelchau, MonicaUNSPECIFIEDorcid.org/0000-0002-4584-6056UNSPECIFIED
Jennings, Emily C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Szuter, Elise M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hagan, Richard W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gujar, HemantUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shukla, Jayendra NathUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zhu, FangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mohan, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nelson, David R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rosendale, Andrew J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Derst, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Resnik, ValentinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wernig, SebastianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Menegazzi, PamelaUNSPECIFIEDorcid.org/0000-0001-5232-1920UNSPECIFIED
Wegener, ChristianUNSPECIFIEDorcid.org/0000-0003-4481-3567UNSPECIFIED
Peschel, NicolaiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hendershot, Jacob M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Blenau, WolfgangUNSPECIFIEDorcid.org/0000-0002-6874-4730UNSPECIFIED
Predel, ReinhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Johnston, Paul R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ioannidis, PanagiotisUNSPECIFIEDorcid.org/0000-0003-0939-6745UNSPECIFIED
Waterhouse, Robert M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nauen, RalfUNSPECIFIEDorcid.org/0000-0002-7525-8589UNSPECIFIED
Schorn, CorinnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ott, Mark-ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maiwald, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Johnston, J. SpencerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gondhalekar, Ameya D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scharf, Michael E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Peterson, Brittany F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Raje, Kapil R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hottel, Benjamin A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Armisen, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Crumiere, Antonin Jean JohanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Refki, Peter NaguiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Santos, Maria EmiliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sghaier, EssiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Viala, SeverineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Khila, AbderrahmanUNSPECIFIEDorcid.org/0000-0003-0908-483XUNSPECIFIED
Ahn, Seung-JoonUNSPECIFIEDorcid.org/0000-0002-5980-106XUNSPECIFIED
Childers, ChristopherUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lee, Chien-YuehUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lin, HanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hughes, Daniel S. T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Duncan, Elizabeth J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Murali, Shwetha C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Qu, JiaxinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dugan, ShannonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lee, Sandra L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chao, HsuUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dinh, HuyenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Han, YiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Doddapaneni, HarshavardhanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Worley, Kim C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Muzny, Donna M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wheeler, DavidUNSPECIFIEDorcid.org/0000-0001-5538-8119UNSPECIFIED
Panfilio, Kristen A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jentzsch, Iris M. VargasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vargo, Edward L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Booth, WarrenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Friedrich, MarkusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weirauch, Matthew T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Anderson, Michelle A. E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jones, Jeffery W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mittapalli, OmprakashUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zhao, ChaoyangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zhou, Jing-JiangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Evans, Jay D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Attardo, Geoffrey M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Robertson, Hugh M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zdobnov, Evgeny M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ribeiro, Jose M. C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gibbs, Richard A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Werren, John H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Palli, Subba R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schal, CobyUNSPECIFIEDorcid.org/0000-0001-7195-6358UNSPECIFIED
Richards, StephenUNSPECIFIEDorcid.org/0000-0001-8959-5466UNSPECIFIED
URN: urn:nbn:de:hbz:38-286574
DOI: 10.1038/ncomms10165
Journal or Publication Title: Nat. Commun.
Volume: 7
Date: 2016
Publisher: NATURE PUBLISHING GROUP
Place of Publication: LONDON
ISSN: 2041-1723
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CIMEX-LECTULARIUS L.; INSECTICIDE RESISTANCE; TRAUMATIC INSEMINATION; GENE FAMILY; R CONSENSUS; RECEPTORS; WOLBACHIA; ANNOTATION; PROTEINS; CLASSIFICATIONMultiple languages
Multidisciplinary SciencesMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/28657

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