Universität zu Köln

Wai, Timothy ORCID: 0000-0002-6770-6222 and Langer, Thomas ORCID: 0000-0003-1250-1462 (2016). Mitochondrial Dynamics and Metabolic Regulation. Trends Endocrinol. Metab., 27 (2). S. 105 - 118. LONDON: ELSEVIER SCIENCE LONDON. ISSN 1879-3061

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Abstract

Mitochondrial morphology varies tremendously across cell types and tissues, changing rapidly in response to external insults and metabolic cues, such as nutrient status. The many functions of mitochondria have been intimately linked to their morphology, which is shaped by ongoing events of fusion and fission of outer and inner membranes (OM and IM). Unopposed fission causes mitochondrial fragmentation, which is generally associated with metabolic dysfunction and disease. Unopposed fusion results in a hyperfused network and serves to counteract metabolic insults, preserve cellular integrity, and protect against autophagy. Here, we review the ways in which metabolic alterations convey changes in mitochondrial morphology and how disruption of mitochondrial morphology impacts cellular and organismal metabolism.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wai, Timothy UNSPECIFIED orcid.org/0000-0002-6770-6222 UNSPECIFIED Langer, Thomas UNSPECIFIED orcid.org/0000-0003-1250-1462 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-286739
DOI:	10.1016/j.tem.2015.12.001
Journal or Publication Title:	Trends Endocrinol. Metab.
Volume:	27
Number:	2
Page Range:	S. 105 - 118
Date:	2016
Publisher:	ELSEVIER SCIENCE LONDON
Place of Publication:	LONDON
ISSN:	1879-3061
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language STOMATIN-LIKE PROTEIN-2; SKELETAL-MUSCLE; MITOFUSIN 2; E3 LIGASE; PROTEOLYTIC CLEAVAGE; INSULIN-RESISTANCE; NUAGE FORMATION; OPTIC ATROPHY; CELL-DEATH; FISSION Multiple languages Endocrinology & Metabolism Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/28673