May, Margaret T., Gill, Michael J., Wittkop, Linda ORCID: 0000-0003-2403-0960, Klein, Marina, Sabin, Caroline ORCID: 0000-0001-5173-2760, Harrigan, P. Richard, Dunn, David, Vehreschild, Jorg Janne, Rubio, Rafael, Mocroft, Amanda, Cavassini, Matthias, Reiss, Peter, Monforte, Antonella D'Arminio, Zangerle, Robert, Ingle, Suzanne M., Hill, Teresa, Jose, Sophie, Sterne, Jonathan A. C., Boulle, Andrew ORCID: 0000-0002-7713-8062, Stephan, Christoph, Miro, Jose M., Cavassini, Matthias, Chene, Gene-Vieve, Costagliola, Dominique, Dabis, Francois, Monforte, Antonella D'Arminio, del Amo, Julia, Van Sighem, Ard, Vehreschild, Jorg, Gill, John, Guest, Jodie ORCID: 0000-0002-3650-3975, Haerry, David Hans-Ulrich, Hogg, Robert, Justice, Amy, Mocroft, Amanda, Obel, Niels, Crane, Heidi, Smith, Colette ORCID: 0000-0003-2847-3355, Reiss, Peter, Saag, Michael, Sterling, Tim, Teira, Ramon, Williams, Matthew, Zangerle, Robert, Sterne, Jonathan ORCID: 0000-0001-8496-6053, May, Margaret, Ingle, Suzanne, Trickey, Adam, Ainsworth, Jonathan, Anderson, Jane ORCID: 0000-0001-5294-8707, Babiker, Abdel, Chadwick, David, Delpech, Valerie, Dunn, David, Fisher, Martin, Gazzard, Brian, Gilson, Richard, Hay, Phillip, Gompels, Mark, Hill, Teresa, Johnson, Margaret, Jose, Sophie, Kegg, Stephen, Leen, Clifford, Mackie, Nicky, Nelson, Mark, Orkin, Chloe, Palfreeman, Adrian, Phillips, Andrew, Pillay, Deenan, Post, Frank, Sabin, Caroline ORCID: 0000-0001-5173-2760, Sachikonye, Memory, Schwenk, Achim, Walsh, John, Thornton, Alicia, Huntington, Susie, Glabay, Adam, Orkin, Chloe, Garrett, Nigel, Lynch, Janet, Hand, James, de Souza, Carl, Fisher, Martin, Perry, Nicky, Tilbury, Stuart, Youssef, Elaney, Churchill, Duncan, Gazzard, Brian, Nelson, Mark, Waxman, Matthew, Asboe, David, Mandalia, Sundhiya, Anderson, Jane ORCID: 0000-0001-5294-8707, Munshi, Sajid, Awosika, Damilola, Post, Frank, Korat, Hardik, Taylor, Chris, Gleisner, Zachary, Ibrahim, Fowzia, Campbell, Lucy, Babiker, Abdel, Dunn, David, Glabay, Adam, Chadwick, David, Baillie, Kirsty, Cope, Emma, Gibney, Marie, Gibson, Jane, Gilson, Richard, Brima, Nataliya, Williams, Ian, Ainsworth, Jonathan, Schwenk, Achim, Miller, Sheila, Wood, Chris, Johnson, Margaret, Youle, Mike, Lampe, Fiona ORCID: 0000-0001-6851-5471, Smith, Colette ORCID: 0000-0003-2847-3355, Chaloner, Clinton, Hill, Teresa, Huntington, Susie, Jose, Sophie, Phillips, Andrew, Sabin, Caroline ORCID: 0000-0001-5173-2760, Thornton, Alicia, Walsh, John, Mackie, Nicky, Winston, Alan, Weber, Jonathan, Ramzan, Farhan, Carder, Mark, Leen, Clifford, Wilson, Alan, Morris, Sheila, Gompels, Mark, Allan, Sue, Palfreeman, Adrian, Moore, Anne, Fox, Lynn, Bojanowski, Josef, Lewszuk, Adam, Kegg, Stephen, Main, Paul, Mitchell, Dr, Hunter, Dr, Sachikonye, Memory, Hay, Phillip, Dhillon, Mandip, Martin, Fabiola, Douglas, Sarah and Russell-Sharp, Sarah
(2016).
Mortality of treated HIV-1 positive individuals according to viral subtype in Europe and Canada: collaborative cohort analysis.
Aids, 30 (3).
S. 503 - 514.
PHILADELPHIA:
LIPPINCOTT WILLIAMS & WILKINS.
ISSN 1473-5571
Full text not available from this repository.
Abstract
Objectives:To estimate prognosis by viral subtype in HIV-1-infected individuals from start of antiretroviral therapy (ART) and after viral failure.Design:Collaborative analysis of data from eight European and three Canadian cohorts.Methods:Adults (N>20000) who started triple ART between 1996 and 2012 and had data on viral subtype were followed for mortality. We estimated crude and adjusted (for age, sex, regimen, CD4(+) cell count, and AIDS at baseline, period of starting ART, stratified by cohort, region of origin and risk group) mortality hazard ratios (MHR) by subtype. We estimated MHR subsequent to viral failure defined as two HIV-RNA measurements greater than 500 copies/ml after achieving viral suppression.Results:The most prevalent subtypes were B (15419; 74%), C (2091; 10%), CRF02AG (1057; 5%), A (873; 4%), CRF01AE (506; 2.4%), G (359; 1.7%), and D (232; 1.1%). Subtypes were strongly patterned by region of origin and risk group. During 104649 person-years of observation, 1172/20784 patients died. Compared with subtype B, mortality was higher for subtype A, but similar for all other subtypes. MHR for A versus B were 1.13 (95% confidence interval 0.85,1.50) when stratified by cohort, increased to 1.78 (1.27,2.51) on stratification by region and risk, and attenuated to 1.59 (1.14,2.23) on adjustment for covariates. MHR for A versus B was 2.65 (1.64,4.28) and 0.95 (0.57,1.57) for patients who started ART with CD4(+) cell count below, or more than, 100 cells/l, respectively. There was no difference in mortality between subtypes A, B and C after viral failure.Conclusion:Patients with subtype A had worse prognosis, an observation which may be confounded by socio-demographic factors. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.
Item Type: |
Journal Article
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Creators: |
Creators | Email | ORCID | ORCID Put Code |
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May, Margaret T. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Gill, Michael J. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Wittkop, Linda | UNSPECIFIED | orcid.org/0000-0003-2403-0960 | UNSPECIFIED | Klein, Marina | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Sabin, Caroline | UNSPECIFIED | orcid.org/0000-0001-5173-2760 | UNSPECIFIED | Harrigan, P. Richard | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Dunn, David | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Vehreschild, Jorg Janne | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Rubio, Rafael | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Mocroft, Amanda | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Cavassini, Matthias | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Reiss, Peter | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Monforte, Antonella D'Arminio | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Zangerle, Robert | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Ingle, Suzanne M. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Hill, Teresa | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Jose, Sophie | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Sterne, Jonathan A. C. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Boulle, Andrew | UNSPECIFIED | orcid.org/0000-0002-7713-8062 | UNSPECIFIED | Stephan, Christoph | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Miro, Jose M. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Cavassini, Matthias | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Chene, Gene-Vieve | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Costagliola, Dominique | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Dabis, Francois | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Monforte, Antonella D'Arminio | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | del Amo, Julia | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Van Sighem, Ard | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Vehreschild, Jorg | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Gill, John | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Guest, Jodie | UNSPECIFIED | orcid.org/0000-0002-3650-3975 | UNSPECIFIED | Haerry, David Hans-Ulrich | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Hogg, Robert | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Justice, Amy | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Mocroft, Amanda | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Obel, Niels | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Crane, Heidi | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Smith, Colette | UNSPECIFIED | orcid.org/0000-0003-2847-3355 | UNSPECIFIED | Reiss, Peter | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Saag, Michael | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Sterling, Tim | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Teira, Ramon | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Williams, Matthew | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Zangerle, Robert | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Sterne, Jonathan | UNSPECIFIED | orcid.org/0000-0001-8496-6053 | UNSPECIFIED | May, Margaret | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Ingle, Suzanne | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Trickey, Adam | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Ainsworth, Jonathan | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Anderson, Jane | UNSPECIFIED | orcid.org/0000-0001-5294-8707 | UNSPECIFIED | Babiker, Abdel | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Chadwick, David | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Delpech, Valerie | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Dunn, David | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Fisher, Martin | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Gazzard, Brian | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Gilson, Richard | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Hay, Phillip | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Gompels, Mark | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Hill, Teresa | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Johnson, Margaret | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Jose, Sophie | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Kegg, Stephen | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Leen, Clifford | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Mackie, Nicky | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Nelson, Mark | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Orkin, Chloe | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Palfreeman, Adrian | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Phillips, Andrew | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Pillay, Deenan | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Post, Frank | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Sabin, Caroline | UNSPECIFIED | orcid.org/0000-0001-5173-2760 | UNSPECIFIED | Sachikonye, Memory | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Schwenk, Achim | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Walsh, John | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Thornton, Alicia | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Huntington, Susie | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Glabay, Adam | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Orkin, Chloe | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Garrett, Nigel | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Lynch, Janet | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Hand, James | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | de Souza, Carl | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Fisher, Martin | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Perry, Nicky | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Tilbury, Stuart | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Youssef, Elaney | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Churchill, Duncan | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Gazzard, Brian | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Nelson, Mark | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Waxman, Matthew | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Asboe, David | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Mandalia, Sundhiya | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Anderson, Jane | UNSPECIFIED | orcid.org/0000-0001-5294-8707 | UNSPECIFIED | Munshi, Sajid | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Awosika, Damilola | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Post, Frank | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Korat, Hardik | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Taylor, Chris | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Gleisner, Zachary | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Ibrahim, Fowzia | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Campbell, Lucy | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Babiker, Abdel | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Dunn, David | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Glabay, Adam | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Chadwick, David | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Baillie, Kirsty | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Cope, Emma | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Gibney, Marie | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Gibson, Jane | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Gilson, Richard | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Brima, Nataliya | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Williams, Ian | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Ainsworth, Jonathan | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Schwenk, Achim | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Miller, Sheila | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Wood, Chris | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Johnson, Margaret | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Youle, Mike | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Lampe, Fiona | UNSPECIFIED | orcid.org/0000-0001-6851-5471 | UNSPECIFIED | Smith, Colette | UNSPECIFIED | orcid.org/0000-0003-2847-3355 | UNSPECIFIED | Chaloner, Clinton | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Hill, Teresa | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Huntington, Susie | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Jose, Sophie | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Phillips, Andrew | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Sabin, Caroline | UNSPECIFIED | orcid.org/0000-0001-5173-2760 | UNSPECIFIED | Thornton, Alicia | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Walsh, John | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Mackie, Nicky | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Winston, Alan | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Weber, Jonathan | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Ramzan, Farhan | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Carder, Mark | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Leen, Clifford | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Wilson, Alan | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Morris, Sheila | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Gompels, Mark | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Allan, Sue | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Palfreeman, Adrian | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Moore, Anne | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Fox, Lynn | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Bojanowski, Josef | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Lewszuk, Adam | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Kegg, Stephen | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Main, Paul | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Mitchell, Dr | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Hunter, Dr | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Sachikonye, Memory | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Hay, Phillip | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Dhillon, Mandip | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Martin, Fabiola | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Douglas, Sarah | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Russell-Sharp, Sarah | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED |
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URN: |
urn:nbn:de:hbz:38-286932 |
DOI: |
10.1097/QAD.0000000000000941 |
Journal or Publication Title: |
Aids |
Volume: |
30 |
Number: |
3 |
Page Range: |
S. 503 - 514 |
Date: |
2016 |
Publisher: |
LIPPINCOTT WILLIAMS & WILKINS |
Place of Publication: |
PHILADELPHIA |
ISSN: |
1473-5571 |
Language: |
English |
Faculty: |
Unspecified |
Divisions: |
Unspecified |
Subjects: |
no entry |
Uncontrolled Keywords: |
Keywords | Language |
---|
COMBINATION ANTIRETROVIRAL THERAPY; T-CELL DECLINE; DISEASE PROGRESSION; IMMUNOLOGICAL RESPONSE; TYPE-1 SUBTYPES; NAIVE PATIENTS; IMPACT; DIVERSITY; INFECTIONS; RESISTANCE | Multiple languages | Immunology; Infectious Diseases; Virology | Multiple languages |
|
Refereed: |
Yes |
URI: |
http://kups.ub.uni-koeln.de/id/eprint/28693 |
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