Duhan, Vikas ORCID: 0000-0002-6337-8225, Khairnar, Vishal ORCID: 0000-0002-3584-7530, Friedrich, Sarah-Kim, Zhou, Fan, Gassa, Asmae, Honke, Nadine, Shaabani, Namir, Gailus, Nicole, Botezatu, Lacramioara, Khandanpour, Cyrus ORCID: 0000-0003-4655-6269, Dittmer, Ulf, Haeussinger, Dieter, Recher, Mike ORCID: 0000-0002-9121-6936, Hardt, Cornelia, Lang, Philipp A. and Lang, Karl S. (2016). Virus-specific antibodies allow viral replication in the marginal zone, thereby promoting CD8(+)T-cell priming and viral control. Sci Rep, 6. LONDON: NATURE PUBLISHING GROUP. ISSN 2045-2322

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Abstract

Clinically used human vaccination aims to induce specific antibodies that can guarantee long-term protection against a pathogen. The reasons that other immune components often fail to induce protective immunity are still debated. Recently we found that enforced viral replication in secondary lymphoid organs is essential for immune activation. In this study we used the lymphocytic choriomeningitis virus (LCMV) to determine whether enforced virus replication occurs in the presence of virus-specific antibodies or virus-specific CD8(+)T cells. We found that after systemic recall infection with LCMV-WE the presence of virus-specific antibodies allowed intracellular replication of virus in the marginal zone of spleen. In contrast, specific antibodies limited viral replication in liver, lung, and kidney. Upon recall infection with the persistent virus strain LCMV-Docile, viral replication in spleen was essential for the priming of CD8(+)T cells and for viral control. In contrast to specific antibodies, memory CD8(+)T cells inhibited viral replication in marginal zone but failed to protect mice from persistent viral infection. We conclude that virus-specific antibodies limit viral infection in peripheral organs but still allow replication of LCMV in the marginal zone, a mechanism that allows immune boosting during recall infection and thereby guarantees control of persistent virus.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Duhan, VikasUNSPECIFIEDorcid.org/0000-0002-6337-8225UNSPECIFIED
Khairnar, VishalUNSPECIFIEDorcid.org/0000-0002-3584-7530UNSPECIFIED
Friedrich, Sarah-KimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zhou, FanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gassa, AsmaeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Honke, NadineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shaabani, NamirUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gailus, NicoleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Botezatu, LacramioaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Khandanpour, CyrusUNSPECIFIEDorcid.org/0000-0003-4655-6269UNSPECIFIED
Dittmer, UlfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haeussinger, DieterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Recher, MikeUNSPECIFIEDorcid.org/0000-0002-9121-6936UNSPECIFIED
Hardt, CorneliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lang, Philipp A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lang, Karl S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-287015
DOI: 10.1038/srep19191
Journal or Publication Title: Sci Rep
Volume: 6
Date: 2016
Publisher: NATURE PUBLISHING GROUP
Place of Publication: LONDON
ISSN: 2045-2322
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CD8 T-CELLS; IMMUNOLOGICAL MEMORY; PROTECTIVE IMMUNITY; HIV-INFECTION; HEPATITIS-C; RESPONSES; VACCINE; ACTIVATIONMultiple languages
Multidisciplinary SciencesMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/28701

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