Universität zu Köln

Biehl, Lena M., Schmidt-Hieber, Martin, Liss, Blasius, Cornely, Oliver A. and Vehreschild, Maria J. G. T. (2016). Colonization and infection with extended spectrum beta-lactamase producing Enterobacteriaceae in high-risk patients - Review of the literature from a clinical perspective. Crit. Rev. Microbiol., 42 (1). S. 1 - 17. ABINGDON: TAYLOR & FRANCIS LTD. ISSN 1549-7828

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Abstract

Background: The prevalence of extended-spectrum -lactamase producing Enterobacteriaceae (ESBL-E) is increasing worldwide. ESBL-E are known to colonize different body sites and cause bloodstream infections (BSI), pneumonia, intra-abdominal infections and urinary tract infections. Even though ESBL-E-related morbidity and mortality in high-risk patients - patients receiving immunosuppressants or chemotherapy, as well as those treated in an ICU - is considerable, the management of ESBL-E in these populations has not been systematically reviewed. Methods: For the purpose of this review, ICU patients, patients in hematology and oncology wards and transplant recipients were considered high-risk. An English-language Medline search was conducted to identify literature on epidemiology, risk factors, clinical impact and measures of infection control regarding ESBL-E in high-risk patients published between June 2002 and May 2013. Results: Using the above described methodology, 43 relevant articles regarding high-risk patients and - for areas where literature on exclusively high-risk patients is scarce - 17 articles in standard risk settings were identified. The evidence on epidemiology, associated risk factors, treatment and hygiene measures were summarized. Discussion: This review gives a complete overview on the management of ESBL-E in the high-risk setting.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Biehl, Lena M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmidt-Hieber, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Liss, Blasius UNSPECIFIED UNSPECIFIED UNSPECIFIED Cornely, Oliver A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Vehreschild, Maria J. G. T. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-287752
DOI:	10.3109/1040841X.2013.875515
Journal or Publication Title:	Crit. Rev. Microbiol.
Volume:	42
Number:	1
Page Range:	S. 1 - 17
Date:	2016
Publisher:	TAYLOR & FRANCIS LTD
Place of Publication:	ABINGDON
ISSN:	1549-7828
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BLOOD-STREAM INFECTIONS; INTENSIVE-CARE-UNIT; DIGESTIVE-TRACT DECONTAMINATION; CEPHALOSPORIN-RESISTANT ENTEROBACTERIACEAE; KLEBSIELLA-PNEUMONIAE BACTEREMIA; GRAM-NEGATIVE BACTERIA; ESCHERICHIA-COLI; FECAL CARRIAGE; 3RD-GENERATION CEPHALOSPORINS; SELECTIVE DECONTAMINATION Multiple languages Microbiology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/28775