Universität zu Köln

Tzivian, Lilian ORCID: 0000-0001-6253-9130, Dlugaj, Martha, Winkler, Angela, Hennig, Frauke, Fuks, Kateryna, Sugiri, Dorothee, Schikowski, Tamara, Jakobs, Hermann, Erbel, Raimund, Joeckel, Karl-Heinz, Moebus, Susanne, Hoffmann, Barbara and Weimar, Christian (2016). Long-term air pollution and traffic noise exposures and cognitive function:A cross-sectional analysis of the Heinz Nixdorf Recall study. J. Toxicol. Env. Health Part A, 79 (22-23). S. 1057 - 1070. PHILADELPHIA: TAYLOR & FRANCIS INC. ISSN 1087-2620

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Abstract

Investigations of adverse effects of air pollution (AP) and ambient noise on cognitive functions are apparently scarce, and findings seem to be inconsistent. The aim of this study was to examine the associations of long-term exposure to AP and traffic noise with cognitive performance. At the second examination of the population-based Heinz Nixdorf Recall study (2006-2008), cognitive performance was evaluated in 4086 participants. Long-term residential exposure to size-specific particulate matter (PM) and nitrogen oxides (NOx) with land use regression, to and traffic noise (weighted 24-h (L-DEN) and nighttime (L-NIGHT) means), was assessed according to the European Union (EU) Directive 2002/49/EC. Multiple regression models were calculated for the relationship of environmental exposures with a global cognitive score (GCS) and in five cognitive subtests, using single- and two-exposure models. In fully adjusted models, several AP metrics were negatively associated with four of five subtests and with GCS. For example, an interquartile range increase in PM2.5 was correlated with verbal fluency, labyrinth test, and immediate and delayed verbal recall. A 10 dB(A) elevation in L-DEN and L-NIGHT was associated with GCS. Similar but not significant associations were found for the cognitive subtests. In two-exposure models including noise and air pollution simultaneously, the associations did not change markedly for air pollution, but attenuated numerically for noise. Long-term exposures to AP and traffic noise are negatively correlated with subtests related to memory and executive functions. There appears to be little evidence for mutual confounding.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Tzivian, Lilian UNSPECIFIED orcid.org/0000-0001-6253-9130 UNSPECIFIED Dlugaj, Martha UNSPECIFIED UNSPECIFIED UNSPECIFIED Winkler, Angela UNSPECIFIED UNSPECIFIED UNSPECIFIED Hennig, Frauke UNSPECIFIED UNSPECIFIED UNSPECIFIED Fuks, Kateryna UNSPECIFIED UNSPECIFIED UNSPECIFIED Sugiri, Dorothee UNSPECIFIED UNSPECIFIED UNSPECIFIED Schikowski, Tamara UNSPECIFIED UNSPECIFIED UNSPECIFIED Jakobs, Hermann UNSPECIFIED UNSPECIFIED UNSPECIFIED Erbel, Raimund UNSPECIFIED UNSPECIFIED UNSPECIFIED Joeckel, Karl-Heinz UNSPECIFIED UNSPECIFIED UNSPECIFIED Moebus, Susanne UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoffmann, Barbara UNSPECIFIED UNSPECIFIED UNSPECIFIED Weimar, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-288399
DOI:	10.1080/15287394.2016.1219570
Journal or Publication Title:	J. Toxicol. Env. Health Part A
Volume:	79
Number:	22-23
Page Range:	S. 1057 - 1070
Date:	2016
Publisher:	TAYLOR & FRANCIS INC
Place of Publication:	PHILADELPHIA
ISSN:	1087-2620
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PARTICULATE MATTER; OXIDATIVE STRESS; VERBAL FLUENCY; ASSOCIATION; IMPAIRMENT; DISEASE; PARTICLES; HEALTH; PERFORMANCE; PREVALENCE Multiple languages Environmental Sciences; Public, Environmental & Occupational Health; Toxicology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/28839