Universität zu Köln

Erren, T. C., Morfeld, P., Foster, R. G., Reiter, R. J., Gross, J. V. and Westermann, I. K. (2016). Sleep and cancer: Synthesis of experimental data and meta-analyses of cancer incidence among some 1,500,000 study individuals in 13 countries. Chronobiol. Int., 33 (4). S. 325 - 351. PHILADELPHIA: TAYLOR & FRANCIS INC. ISSN 1525-6073

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Abstract

Sleep and its impact on physiology and pathophysiology are researched at an accelerating pace and from many different angles. Experiments provide evidence for chronobiologically plausible links between chronodisruption and sleep and circadian rhythm disruption (SCRD), on the one hand, and the development of cancer, on the other. Epidemiological evidence from cancer incidence among some 1 500 000 study individuals in 13 countries regarding associations with sleep duration, napping or poor sleep is variable and inconclusive. Combined adjusted relative risks (meta-RRs) for female breast cancer, based on heterogeneous data, were 1.01 (95% CI: 0.97-1.06). Meta-RRs for cancers of the colorectum and of the lung in women and men and for prostate cancer were 1.08 (95% CI: 1.03-1.13), 1.11 (95% CI: 1.00-1.22) and 1.05 (95% CI: 0.83-1.33), respectively. The significantly increased meta-RRs for colorectal cancer, based on homogeneous data, warrant targeted study. However, the paramount epidemiological problem inhibiting valid conclusions about the associations between sleep and cancer is the probable misclassification of the exposures to facets of sleep over time. Regarding the inevitable conclusion that more research is needed to answer How are sleep and cancer linked in humans? we offer eight sets of recommendations for future studies which must take note of the complexity of multidirectional relationships.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Erren, T. C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Morfeld, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Foster, R. G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Reiter, R. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gross, J. V. UNSPECIFIED UNSPECIFIED UNSPECIFIED Westermann, I. K. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-289565
DOI:	10.3109/07420528.2016.1149486
Journal or Publication Title:	Chronobiol. Int.
Volume:	33
Number:	4
Page Range:	S. 325 - 351
Date:	2016
Publisher:	TAYLOR & FRANCIS INC
Place of Publication:	PHILADELPHIA
ISSN:	1525-6073
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NIGHT-SHIFT WORK; CIRCADIAN-RHYTHM DISRUPTION; CHRONIC JET-LAG; BREAST-CANCER; COLORECTAL-CANCER; PROSTATE-CANCER; LUNG-CANCER; TEXTILE WORKERS; AIRCRAFT NOISE; RISK Multiple languages Biology; Physiology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/28956