Universität zu Köln

Dafsari, Haidar Salimi, Reddy, Prashanth, Herchenbach, Christiane, Wawro, Stefanie, Petry-Schmelzer, Jan Niklas ORCID: 0000-0003-0749-3840, Visser-Vandewalle, Veerle, Rizos, Alexandra, Silverdale, Monty ORCID: 0000-0002-3295-6897, Ashkan, Keyoumars, Samuel, Michael, Evans, Julian, Huber, Carlo A., Fink, Gereon R. ORCID: 0000-0002-8230-1856, Antonini, Angelo ORCID: 0000-0003-1040-2807, Chaudhuri, K. Ray, Martinez-Martin, Pablo ORCID: 0000-0003-0837-5280 and Timmermann, Lars (2016). Beneficial Effects of Bilateral Subthalamic Stimulation on Non-Motor Symptoms in Parkinson's Disease. Brain Stimul., 9 (1). S. 78 - 86. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1876-4754

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Abstract

Background: STN-DBS is well established to improve motor symptoms and quality of life in patients with PD. While non-motor symptoms are crucial for quality of life in these patients, only neuropsychiatric and neuropsychological symptoms have been systematically studied in a longitudinal design so far. However, these are only a part of the non-motor symptoms spectrum. Hypothesis: We hypothesized that STN-DBS is associated with a beneficial effect on a range of non-motor symptoms. Methods: In this multicenter, open, prospective, international study (EuroInf-study, UKCRN10084/ DRKS00006735) we investigated non-motor effects of STN-DBS in real-life use. We evaluated Nonmotor Symptom Scale, and Questionnaire, PD Questionnaire-8, Scales for Outcomes of PD motor examination and complications, and activities of daily living preoperatively and at 6 months follow-up in 60 consecutive patients (35 male, mean age: 61.6 +/- 7.8 years, mean disease duration: 10.4 +/- 4.2 years). Results: All outcomes improved significantly at 6 months follow-up (PD Questionaire-8, p = 0.006; activities of daily living, p = 0.012; all others, p < 0.001; Wilcoxon signed-rank, respectively paired t-test; Bonferroni-correction). Post-hoc analyses of Non-motor Symptom Scale domains showed a significant reduction of sleep/fatigue and miscellaneous domains (p = 0.001), perceptual problems/hallucinations (p = 0.036), and urinary (p = 0.018) scores. Effect sizes were moderate for Non-motor Symptom Scale, and motor complications, large for motor examination, and small for other outcomes.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Dafsari, Haidar Salimi UNSPECIFIED UNSPECIFIED UNSPECIFIED Reddy, Prashanth UNSPECIFIED UNSPECIFIED UNSPECIFIED Herchenbach, Christiane UNSPECIFIED UNSPECIFIED UNSPECIFIED Wawro, Stefanie UNSPECIFIED UNSPECIFIED UNSPECIFIED Petry-Schmelzer, Jan Niklas UNSPECIFIED orcid.org/0000-0003-0749-3840 UNSPECIFIED Visser-Vandewalle, Veerle UNSPECIFIED UNSPECIFIED UNSPECIFIED Rizos, Alexandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Silverdale, Monty UNSPECIFIED orcid.org/0000-0002-3295-6897 UNSPECIFIED Ashkan, Keyoumars UNSPECIFIED UNSPECIFIED UNSPECIFIED Samuel, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Evans, Julian UNSPECIFIED UNSPECIFIED UNSPECIFIED Huber, Carlo A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Antonini, Angelo UNSPECIFIED orcid.org/0000-0003-1040-2807 UNSPECIFIED Chaudhuri, K. Ray UNSPECIFIED UNSPECIFIED UNSPECIFIED Martinez-Martin, Pablo UNSPECIFIED orcid.org/0000-0003-0837-5280 UNSPECIFIED Timmermann, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-292450
DOI:	10.1016/j.brs.2015.08.005
Journal or Publication Title:	Brain Stimul.
Volume:	9
Number:	1
Page Range:	S. 78 - 86
Date:	2016
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1876-4754
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DEEP-BRAIN-STIMULATION; QUALITY-OF-LIFE; OLFACTORY FUNCTION; INTRAJEJUNAL LEVODOPA; CONVENTIONAL THERAPY; NUCLEUS STIMULATION; MOTOR IMPAIRMENTS; MULTICENTER; IMPACT; SLEEP Multiple languages Clinical Neurology; Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/29245