Universität zu Köln

Gassa, Asmae, Jian, Fu, Kalkavan, Halime ORCID: 0000-0002-0090-4080, Duhan, Vikas ORCID: 0000-0002-6337-8225, Honke, Nadine, Shaabani, Namir, Friedrich, Sarah-Kim, Dolff, Sebastian ORCID: 0000-0001-5549-1706, Wahlers, Thorsten, Kribben, Andreas, Hardt, Cornelia, Lang, Philipp A., Witzke, Oliver and Lang, Karl S. (2016). IL-10 Induces T Cell Exhaustion During Transplantation of Virus Infected Hearts. Cell. Physiol. Biochem., 38 (3). S. 1171 - 1182. BASEL: KARGER. ISSN 1421-9778

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Abstract

Background/Aims: Unexpected transmissions of viral pathogens during solid organ transplantation (SOT) can result in severe, life-threatening diseases in transplant recipients. Immune activation contributes to disease onset. However mechanisms balancing the immune response against transmitted viral infection through organ transplantation remain unknown. Methods & Results: Here we found, using lymphocytic choriomeningitis virus (LCMV), that transplantation of LCMV infected hearts led to exhaustion of virus specific CD8(+) T cells, viral persistence in organs and survival of graft and recipient. Genetic depletion of Interleukin-10 (IL-10) resulted in strong immune activation, graft dysfunction and death of mice, suggesting that IL-10 was a major regulator of CD8(+) T cell exhaustion during SOT. In the presence of memory CD8(+) T cells, virus could be controlled. However sufficient antiviral immune response resulted in acute rejection of transplanted heart. Conclusion: We found that virus transmitted via SOT could not be controlled by naive mice recipients due to IL-10 mediated CD8(+) T cell exhaustion which thereby prevented immunopathology and graft failure whereas memory mice recipients were able to control the virus and induced graft failure. (C) 2016 The Author(s) Published by S. Karger AG, Basel

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Gassa, Asmae UNSPECIFIED UNSPECIFIED UNSPECIFIED Jian, Fu UNSPECIFIED UNSPECIFIED UNSPECIFIED Kalkavan, Halime UNSPECIFIED orcid.org/0000-0002-0090-4080 UNSPECIFIED Duhan, Vikas UNSPECIFIED orcid.org/0000-0002-6337-8225 UNSPECIFIED Honke, Nadine UNSPECIFIED UNSPECIFIED UNSPECIFIED Shaabani, Namir UNSPECIFIED UNSPECIFIED UNSPECIFIED Friedrich, Sarah-Kim UNSPECIFIED UNSPECIFIED UNSPECIFIED Dolff, Sebastian UNSPECIFIED orcid.org/0000-0001-5549-1706 UNSPECIFIED Wahlers, Thorsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Kribben, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Hardt, Cornelia UNSPECIFIED UNSPECIFIED UNSPECIFIED Lang, Philipp A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Witzke, Oliver UNSPECIFIED UNSPECIFIED UNSPECIFIED Lang, Karl S. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-292483
DOI:	10.1159/000443067
Journal or Publication Title:	Cell. Physiol. Biochem.
Volume:	38
Number:	3
Page Range:	S. 1171 - 1182
Date:	2016
Publisher:	KARGER
Place of Publication:	BASEL
ISSN:	1421-9778
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LYMPHOCYTIC CHORIOMENINGITIS VIRUS; INTERNATIONAL-SOCIETY; LUNG-TRANSPLANTATION; ORGAN; DONOR; INTERLEUKIN-10; HEPATITIS; CYTOMEGALOVIRUS; TRANSMISSION; PERSISTENCE Multiple languages Cell Biology; Physiology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/29248