Hartmann, Karin ORCID: 0000-0002-4595-8226, Escribano, Luis, Grattan, Clive, Brockow, Knut, Carter, Melody C., Alvarez-Twose, Ivan ORCID: 0000-0002-1190-4473, Matito, Almudena ORCID: 0000-0002-9547-4844, Broesby-Olsen, Sigurd, Siebenhaar, Frank ORCID: 0000-0003-4532-1644, Lange, Magdalena ORCID: 0000-0002-6967-1393, Niedoszytko, Marek ORCID: 0000-0003-1089-1911, Castells, Mariana, Oude Elberink, Joanna N. G., Bonadonna, Patrizia, Zanotti, Roberta, Hornick, Jason L., Torrelo, Antonio, Grabbe, Juergen, Rabenhorst, Anja, Nedoszytko, Boguslaw, Butterfield, Joseph H., Gotlib, Jason, Reiter, Andreas, Radia, Deepti, Hermine, Olivier ORCID: 0000-0003-2574-3874, Sotlar, Karl, George, Tracy I., Kristensen, Thomas K., Kluin-Nelemans, Hanneke C., Yavuz, Selim, Hagglund, Hans, Sperr, Wolfgang R., Schwartz, Lawrence B., Triggiani, Massimo ORCID: 0000-0001-7318-2093, Maurer, Marcus, Nilsson, Gunnar, Horny, Hans-Peter, Arock, Michel, Orfao, Alberto, Metcalfe, Dean D., Akin, Cem ORCID: 0000-0001-6301-4520 and Valent, Peter ORCID: 0000-0003-0456-5095 (2016). Cutaneous manifestations in patients with mastocytosis: Consensus report of the European Competence Network on Mastocytosis; the American Academy of Allergy, Asthma & Immunology; and the European Academy of Allergology and Clinical Immunology. J. Allergy Clin. Immunol., 137 (1). S. 35 - 46. NEW YORK: MOSBY-ELSEVIER. ISSN 1097-6825

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Abstract

Cutaneous lesions in patients with mastocytosis are highly heterogeneous and encompass localized and disseminated forms. Although a classification and criteria for cutaneous mastocytosis (CM) have been proposed, there remains a need to better define subforms of cutaneous manifestations in patients with mastocytosis. To address this unmet need, an international task force involving experts from different organizations (including the European Competence Network on Mastocytosis; the American Academy of Allergy, Asthma & Immunology; and the European Academy of Allergology and Clinical Immunology) met several times between 2010 and 2014 to discuss the classification and criteria for diagnosis of cutaneous manifestations in patients with mastocytosis. This article provides the major outcomes of these meetings and a proposal for a revised definition and criteria. In particular, we recommend that the typical maculopapular cutaneous lesions (urticaria pigmentosa) should be subdivided into 2 variants, namely a monomorphic variant with small maculopapular lesions, which is typically seen in adult patients, and a polymorphic variant with larger lesions of variable size and shape, which is typically seen in pediatric patients. Clinical observations suggest that the monomorphic variant, if it develops in children, often persists into adulthood, whereas the polymorphic variant may resolve around puberty. This delineationmight have important prognostic implications, and its implementation in diagnostic algorithms and future mastocytosis classifications is recommended. Refinements are also suggested for the diagnostic criteria of CM, removal of telangiectasia macularis eruptiva perstans from the current classification of CM, and removal of the adjunct solitary from the term solitary mastocytoma.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Hartmann, KarinUNSPECIFIEDorcid.org/0000-0002-4595-8226UNSPECIFIED
Escribano, LuisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grattan, CliveUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brockow, KnutUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Carter, Melody C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alvarez-Twose, IvanUNSPECIFIEDorcid.org/0000-0002-1190-4473UNSPECIFIED
Matito, AlmudenaUNSPECIFIEDorcid.org/0000-0002-9547-4844UNSPECIFIED
Broesby-Olsen, SigurdUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Siebenhaar, FrankUNSPECIFIEDorcid.org/0000-0003-4532-1644UNSPECIFIED
Lange, MagdalenaUNSPECIFIEDorcid.org/0000-0002-6967-1393UNSPECIFIED
Niedoszytko, MarekUNSPECIFIEDorcid.org/0000-0003-1089-1911UNSPECIFIED
Castells, MarianaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Oude Elberink, Joanna N. G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bonadonna, PatriziaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zanotti, RobertaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hornick, Jason L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Torrelo, AntonioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grabbe, JuergenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rabenhorst, AnjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nedoszytko, BoguslawUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Butterfield, Joseph H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gotlib, JasonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reiter, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Radia, DeeptiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hermine, OlivierUNSPECIFIEDorcid.org/0000-0003-2574-3874UNSPECIFIED
Sotlar, KarlUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
George, Tracy I.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kristensen, Thomas K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kluin-Nelemans, Hanneke C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yavuz, SelimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hagglund, HansUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sperr, Wolfgang R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schwartz, Lawrence B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Triggiani, MassimoUNSPECIFIEDorcid.org/0000-0001-7318-2093UNSPECIFIED
Maurer, MarcusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nilsson, GunnarUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Horny, Hans-PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arock, MichelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Orfao, AlbertoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Metcalfe, Dean D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Akin, CemUNSPECIFIEDorcid.org/0000-0001-6301-4520UNSPECIFIED
Valent, PeterUNSPECIFIEDorcid.org/0000-0003-0456-5095UNSPECIFIED
URN: urn:nbn:de:hbz:38-292810
DOI: 10.1016/j.jaci.2015.08.034
Journal or Publication Title: J. Allergy Clin. Immunol.
Volume: 137
Number: 1
Page Range: S. 35 - 46
Date: 2016
Publisher: MOSBY-ELSEVIER
Place of Publication: NEW YORK
ISSN: 1097-6825
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
MAST-CELLS; PEDIATRIC MASTOCYTOSIS; URTICARIA PIGMENTOSA; SYSTEMIC MASTOCYTOSIS; ONSET MASTOCYTOSIS; DIAGNOSTIC-CRITERIA; GERMLINE MUTATION; TRYPTASE LEVELS; ADULT PATIENTS; RISK-FACTORSMultiple languages
Allergy; ImmunologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/29281

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