Koppara, Alexander ORCID: 0000-0002-3577-6349, Wolfsgruber, Steffen, Kleineidam, Luca, Schmidtke, Klaus, Froelich, Lutz, Kurz, Alexander, Schulz, Stefanie, Hampel, Harald, Heuser, Isabella, Peters, Oliver, Reischies, Friedel M., Jahn, Holger ORCID: 0000-0003-3607-7651, Luckhaus, Christian, Huell, Michael, Gertz, Hermann-Josef, Schroeder, Johannes, Pantel, Johannes, Rienhoff, Otto, Ruether, Eckart, Henn, Fritz, Wiltfang, Jens ORCID: 0000-0003-1492-5330, Maier, Wolfgang, Jessen, Frank, Kornhuber, Johannes ORCID: 0000-0002-8096-3987 and Wagner, Michael ORCID: 0000-0003-2589-6440 (2016). The Latent Dementia Phenotype delta is Associated with Cerebrospinal Fluid Biomarkers of Alzheimer's Disease and Predicts Conversion to Dementia in Subjects with Mild Cognitive Impairment. J. Alzheimers Dis., 49 (2). S. 547 - 561. AMSTERDAM: IOS PRESS. ISSN 1875-8908

Full text not available from this repository.

Abstract

Background: The recently proposed latent variable delta is a new tool for dementia case finding. It is built in a structural equation modeling framework of cognitive and functional data and constitutes a novel endophenotype for Alzheimer's disease (AD) research and clinical trials. Objective: To investigate the association of delta with AD biomarkers and to compare the prediction of d with established scales for conversion to dementia in patients with mild cognitive impairment (MCI). Methods: Using data from a multicenter memory clinic study, we examined the external associations of the latent variable delta and compared delta with well-established cognitive and functional scales and cognitive-functional composite scores. For that purpose, logistic regressions with cerebrospinal fluid (CSF) biomarkers and conversion to dementia as dependent variables were performed with the investigated scores. The models were tested for significant differences. Results: In patients with MCI, delta based on a broad range of cognitive scales (including the ADAS-cog, the MMSE, and the CERAD neuropsychological battery) predicted an abnormal CSF A beta(42)/tau ratio indicative of AD (n = 340, AUC = 0.78, p < 0.001), and predicted incident dementia within 1-3 years of follow-up (n = 525, AUC= 0.84, p < 0.001). These associations were generally stronger than for any other scale or cognitive-functional composite examined. Homologs of d based on reduced test batteries yielded somewhat lower effects. Conclusion: These findings support the interpretation of d as a construct capturing the disease-related essence of cognitive and functional impairments in patients with MCI and dementia, and suggest that d might become an analytical tool for dementia research.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Koppara, AlexanderUNSPECIFIEDorcid.org/0000-0002-3577-6349UNSPECIFIED
Wolfsgruber, SteffenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kleineidam, LucaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmidtke, KlausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Froelich, LutzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kurz, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schulz, StefanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hampel, HaraldUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heuser, IsabellaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Peters, OliverUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reischies, Friedel M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jahn, HolgerUNSPECIFIEDorcid.org/0000-0003-3607-7651UNSPECIFIED
Luckhaus, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Huell, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gertz, Hermann-JosefUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schroeder, JohannesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pantel, JohannesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rienhoff, OttoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruether, EckartUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Henn, FritzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wiltfang, JensUNSPECIFIEDorcid.org/0000-0003-1492-5330UNSPECIFIED
Maier, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jessen, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kornhuber, JohannesUNSPECIFIEDorcid.org/0000-0002-8096-3987UNSPECIFIED
Wagner, MichaelUNSPECIFIEDorcid.org/0000-0003-2589-6440UNSPECIFIED
URN: urn:nbn:de:hbz:38-293560
DOI: 10.3233/JAD-150257
Journal or Publication Title: J. Alzheimers Dis.
Volume: 49
Number: 2
Page Range: S. 547 - 561
Date: 2016
Publisher: IOS PRESS
Place of Publication: AMSTERDAM
ISSN: 1875-8908
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
NEUROPSYCHOLOGICAL ASSESSMENT; DIFFERENTIAL-DIAGNOSIS; TOTAL SCORE; ADAS-COG; VALIDATION; CERAD; SCALE; VALIDITY; CONSENSUS; CRITERIAMultiple languages
NeurosciencesMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/29356

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item