Bacher, Petra, Rosati, Elisa ORCID: 0000-0002-2635-6422, Esser, Daniela, Martini, Gabriela Rios, Saggau, Carina, Schiminsky, Esther, Dargvainiene, Justina, Schroeder, Ina, Wieters, Imke, Khodamoradi, Yascha, Eberhardt, Fabian, Vehreschild, Maria J. G. T., Neb, Holger, Sonntagbauer, Michael, Conrad, Claudio, Tran, Florian, Rosenstiel, Philip, Markewitz, Robert, Wandinger, Klaus-Peter, Augustin, Max, Rybniker, Jan, Kochanek, Matthias, Leypoldt, Frank, Cornely, Oliver A., Koehler, Philipp ORCID: 0000-0002-7386-7495, Franke, Andre and Scheffold, Alexander ORCID: 0000-0002-0626-343X (2020). Low-Avidity CD4(+) T Cell Responses to SARS-CoV-2 in Unexposed Individuals and Humans with Severe COVID-19. Immunity, 53 (6). S. 1258 - 1277. CAMBRIDGE: CELL PRESS. ISSN 1097-4180

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Abstract

CD4 (+) T cells reactive against SARS-CoV-2 can be found in unexposed individuals, and these are suggested to arise in response to common cold coronavirus (CCCoV) infection. Here, we utilized SARS-CoV-2-reactive CD4(+) T cell enrichment to examine the antigen avidity and clonality of these cells, as well as the relative contribution of CCCoV cross-reactivity. SARS-CoV-2-reactive CD4(+) memory T cells were present in virtually all unexposed individuals examined, displaying low functional avidity and multiple, highly variable cross-reactivities that were not restricted to CCCoVs. SARS-CoV-2-reactive CD4 (+) T cells from COVID-1 9 patients lacked cross-reactivity to CCCoVs, irrespective of strong memory T cell responses against CCCoV in all donors analyzed. In severe but not mild COVID-19, SARS-CoV-2-specific T cells displayed low functional avidity and clonality, despite increased frequencies. Our findings identify low-avidity CD4(+) T cell responses as a hallmark of severe COVID-19 and argue against a protective role for CCCoV-reactive T cells in SARS-CoV-2 infection.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Bacher, PetraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rosati, ElisaUNSPECIFIEDorcid.org/0000-0002-2635-6422UNSPECIFIED
Esser, DanielaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Martini, Gabriela RiosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Saggau, CarinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schiminsky, EstherUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dargvainiene, JustinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schroeder, InaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wieters, ImkeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Khodamoradi, YaschaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eberhardt, FabianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vehreschild, Maria J. G. T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Neb, HolgerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sonntagbauer, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Conrad, ClaudioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tran, FlorianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rosenstiel, PhilipUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Markewitz, RobertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wandinger, Klaus-PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Augustin, MaxUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rybniker, JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kochanek, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Leypoldt, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cornely, Oliver A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koehler, PhilippUNSPECIFIEDorcid.org/0000-0002-7386-7495UNSPECIFIED
Franke, AndreUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scheffold, AlexanderUNSPECIFIEDorcid.org/0000-0002-0626-343XUNSPECIFIED
URN: urn:nbn:de:hbz:38-307981
DOI: 10.1016/j.immuni.2020.11.016
Journal or Publication Title: Immunity
Volume: 53
Number: 6
Page Range: S. 1258 - 1277
Date: 2020
Publisher: CELL PRESS
Place of Publication: CAMBRIDGE
ISSN: 1097-4180
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
NAIVE; IMMUNITY; TECHNOLOGIES; SPECIFICITY; PROTECTIONMultiple languages
ImmunologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/30798

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