Herhaus, Peter, Lipkova, Jana, Lammer, Felicitas, Yakushev, Igor, Vag, Tibor, Slotta-Huspenina, Julia, Habringer, Stefan, Lapa, Constantin, Pukrop, Tobias, Hellwig, Dirk, Wiestler, Benedikt ORCID: 0000-0002-2963-7772, Buck, Andreas K., Deckert, Martina, Wester, Hans-Juergen, Bassermann, Florian, Schwaiger, Markus, Weber, Wolfgang, Menze, Bjoern and Keller, Ulrich (2020). CXCR4-Targeted PET Imaging of Central Nervous System B-Cell Lymphoma. J. Nucl. Med., 61 (12). RESTON: SOC NUCLEAR MEDICINE INC. ISSN 1535-5667

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Abstract

C-X-C chemokine receptor 4 (CXCR4) is a transmembrane chemokine receptor involved in growth, survival, and dissemination of cancer, including aggressive B-cell lymphoma. MRI is the standard imaging technology for central nervous system (CNS) involvement of B-cell lymphoma and provides high sensitivity but moderate specificity. Therefore, novel molecular and functional imaging strategies are urgently required. Methods: In this proof-of-concept study, 11 patients with lymphoma of the CNS (8 primary and 3 secondary involvement) were imaged with the CXCR4-directed PET tracer Ga-68-pentixafor. To evaluate the predictive value of this imaging modality, treatment response, as determined by MRI, was correlated with quantification of CXCR4 expression by Ga-68-pentixafor PET in vivo before initiation of treatment in 7 of 11 patients. Results: Ga-68-pentixafor PET showed excellent contrast with the surrounding brain parenchyma in all patients with active disease. Furthermore, initial CXCR4 uptake determined by PET correlated with subsequent treatment response as assessed by MRI. Conclusion: Ga-68-pentixafor PET represents a novel diagnostic tool for CNS lymphoma with potential implications for theranostic approaches as well as response and risk assessment.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Herhaus, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lipkova, JanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lammer, FelicitasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yakushev, IgorUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vag, TiborUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Slotta-Huspenina, JuliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Habringer, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lapa, ConstantinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pukrop, TobiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hellwig, DirkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wiestler, BenediktUNSPECIFIEDorcid.org/0000-0002-2963-7772UNSPECIFIED
Buck, Andreas K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Deckert, MartinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wester, Hans-JuergenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bassermann, FlorianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schwaiger, MarkusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weber, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Menze, BjoernUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Keller, UlrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-310088
DOI: 10.2967/jnumed.120.241703
Journal or Publication Title: J. Nucl. Med.
Volume: 61
Number: 12
Date: 2020
Publisher: SOC NUCLEAR MEDICINE INC
Place of Publication: RESTON
ISSN: 1535-5667
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
PRIMARY CNS LYMPHOMA; INTERNATIONAL EXTRANODAL LYMPHOMA; WHOLE-BRAIN RADIOTHERAPY; IMMUNOCOMPETENT PATIENTS; CXCR4 EXPRESSION; MULTIPLE-MYELOMA; UNITED-STATES; DIAGNOSIS; METHOTREXATE; SURVIVALMultiple languages
Radiology, Nuclear Medicine & Medical ImagingMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/31008

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