Universität zu Köln

Woelfl, Timo, Rohleder, Cathrin ORCID: 0000-0002-3559-1846, Mueller, Juliane K., Lange, Bettina, Reuter, Anne, Schmidt, Anna Maria, Koethe, Dagmar, Hellmich, Martin and Leweke, F. Markus (2020). Effects of Cannabidiol and Delta-9-Tetrahydrocannabinol on Emotion, Cognition, and Attention: A Double-Blind, Placebo-Controlled, Randomized Experimental Trial in Healthy Volunteers. Front. Psychiatry, 11. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1664-0640

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Abstract

The two main phytocannabinoids-delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD)-have been extensively studied, and it has been shown that THC can induce transient psychosis. At the same time, CBD appears to have no psychotomimetic potential. On the contrary, emerging evidence for CBD's antipsychotic properties suggests that it may attenuate effects induced by THC. Thus, we investigated and compared the effects of THC and CBD administration on emotion, cognition, and attention as well as the impact of CBD pre-treatment on THC effects in healthy volunteers. We performed a placebo-controlled, double-blind, experimental trial (GEI-TCP II; identifier: NCT02487381) with 60 healthy volunteers randomly allocated to four parallel intervention groups, receiving either placebo, 800 mg CBD, 20 mg THC, or both cannabinoids. Subjects underwent neuropsychological tests assessing working memory (Letter Number Sequencing test), cognitive processing speed (Digit Symbol Coding task), attention (d2 Test of Attention), and emotional state (adjective mood rating scale [EWL]). Administration of CBD alone did not influence the emotional state, cognitive performance, and attention. At the same time, THC affected two of six emotional categories-more precisely, the performance-related activity and extraversion-, reduced the cognitive processing speed and impaired the performance on the d2 Test of Attention. Interestingly, pre-treatment with CBD did not attenuate the effects induced by THC. These findings show that the acute intake of CBD itself has no effect per se in healthy volunteers and that a single dose of CBD prior to THC administration was insufficient to mitigate the detrimental impact of THC in the given setting. This is in support of a complex interaction between CBD and THC whose effects are not counterbalanced by CBD under all circumstances.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Woelfl, Timo UNSPECIFIED UNSPECIFIED UNSPECIFIED Rohleder, Cathrin UNSPECIFIED orcid.org/0000-0002-3559-1846 UNSPECIFIED Mueller, Juliane K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lange, Bettina UNSPECIFIED UNSPECIFIED UNSPECIFIED Reuter, Anne UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmidt, Anna Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED Koethe, Dagmar UNSPECIFIED UNSPECIFIED UNSPECIFIED Hellmich, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Leweke, F. Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-311461
DOI:	10.3389/fpsyt.2020.576877
Journal or Publication Title:	Front. Psychiatry
Volume:	11
Date:	2020
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	1664-0640
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BINOCULAR DEPTH INVERSION; SUBJECTIVE STATE; MEMORY; PSYCHOSIS; ANXIETY; DELTA(9)-TETRAHYDROCANNABINOL; CANNABINOIDS; PHARMACOLOGY; MARIJUANA; SYMPTOMS Multiple languages Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/31146