Universität zu Köln

Kinuthia, Urbanus Muthai, Wolf, Anne and Langmann, Thomas (2020). Microglia and Inflammatory Responses in Diabetic Retinopathy. Front. Immunol., 11. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1664-3224

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Abstract

Diabetic retinopathy is a vision-threatening disease affecting neurons and microvasculature of the retina. The development of this disease is associated with the action of inflammatory factors that are connected to the activation of microglial cells, the resident tissue macrophages of the CNS. In the quiescent state, microglial cells help maintain tissue homeostasis in the retina through phagocytosis and control of low-grade inflammation. However, prolonged tissue stress due to hyperglycemia primes microglia to become overly reactive with the concomitant production of pro-inflammatory cytokines and chemokines causing chronic inflammation. In this review, we provide evidence of microglial cell activation and pro-inflammatory molecules associated with the development and progression of diabetic retinopathy. We further highlight innovative animal models that can mimic the disease in humans and discuss strategies in modulating microglial-mediated inflammation as potential therapeutic approaches in managing the disease.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kinuthia, Urbanus Muthai UNSPECIFIED UNSPECIFIED UNSPECIFIED Wolf, Anne UNSPECIFIED UNSPECIFIED UNSPECIFIED Langmann, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-311997
DOI:	10.3389/fimmu.2020.564077
Journal or Publication Title:	Front. Immunol.
Volume:	11
Date:	2020
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	1664-3224
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language STIMULATES TNF-ALPHA; ANGIOGENIC FACTORS; RETINAL MICROGLIA; RAT MICROGLIA; CELL-DEATH; ACTIVATION; MACROPHAGES; EXPRESSION; PHENOTYPE; CYTOKINES Multiple languages Immunology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/31199