Universität zu Köln

Klingelhoefer, Lisa, Kaiser, Maximilian, Sauerbier, Anna, Untucht, Robert, Wienecke, Miriam, Mammadova, Koenuel, Falkenburger, Bjoern, Gregor, Olaf, Chaudhuri, K. Ray and Reichmann, Heinz . Emotional well-being and pain could be a greater determinant of quality of life compared to motor severity in cervical dystonia. J. Neural Transm.. WIEN: SPRINGER WIEN. ISSN 1435-1463

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Abstract

Non-motor symptoms (NMS) occur in patients with cervical dystonia (CD) but with variable frequencies and impact on health-related quality of life (HRQoL). To define non-motor and motor profiles and their respective impact on HRQoL in CD patients using the newly validated Dystonia Non-Motor Symptoms Questionnaire (DNMSQuest). In an observational prospective multicentre case-control study, we enrolled 61 patients with CD and 61 age- and sex-matched healthy controls (HC) comparing demographic data, motor and non-motor symptoms and HRQoL measurements. 95% CD patients reported at least one NMS. Mean total NMS score was significantly higher in CD patients (5.62 +/- 3.33) than in HC (1.74 +/- 1.52; p < 0.001). Pain, insomnia and stigma were the most prevalent NMS and HRQoL was significantly impaired in CD patients compared to HC. There was strong correlation of NMS burden with HRQoL (CDQ-24: r = 0.72, EQ-5D: r = - 0.59; p < 0.001) in CD patients. Regression analysis between HRQoL and NMS suggested that emotional well-being (standardized beta = - 0.352) and pain (standardized beta = - 0.291) had a major impact on HRQoL while, in contrast motor severity had no significant impact in this model. Most NMS with the exception of pain, stigma and ADL did not correlate with motor severity. NMS are highly prevalent in CD patients and occur independent of age, sex, disease duration, duration of botulinum neurotoxin therapy and socio-economic status. Specific NMS such as emotional well-being and pain have a major impact on HRQoL and are more relevant than motor severity.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Klingelhoefer, Lisa UNSPECIFIED UNSPECIFIED UNSPECIFIED Kaiser, Maximilian UNSPECIFIED UNSPECIFIED UNSPECIFIED Sauerbier, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Untucht, Robert UNSPECIFIED UNSPECIFIED UNSPECIFIED Wienecke, Miriam UNSPECIFIED UNSPECIFIED UNSPECIFIED Mammadova, Koenuel UNSPECIFIED UNSPECIFIED UNSPECIFIED Falkenburger, Bjoern UNSPECIFIED UNSPECIFIED UNSPECIFIED Gregor, Olaf UNSPECIFIED UNSPECIFIED UNSPECIFIED Chaudhuri, K. Ray UNSPECIFIED UNSPECIFIED UNSPECIFIED Reichmann, Heinz UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-312212
DOI:	10.1007/s00702-020-02274-z
Journal or Publication Title:	J. Neural Transm.
Publisher:	SPRINGER WIEN
Place of Publication:	WIEN
ISSN:	1435-1463
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NONMOTOR SYMPTOMS; PARKINSONS-DISEASE; FOCAL DYSTONIA; IMPACT; MULTICENTER; QUESTIONNAIRE; FREQUENCY; SLEEP; MOCA Multiple languages Clinical Neurology; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/31221