Wu, Hemmings, Hariz, Marwan, Visser-Vandewalle, Veerle, Zrinzo, Ludvic ORCID: 0000-0002-6013-4946, Coenen, Volker A., Sheth, Sameer A., Bervoets, Chris, Naesstrom, Matilda, Blomstedt, Patric, Coyne, Terry, Hamani, Clement, Slavin, Konstantin, Krauss, Joachim K., Kahl, Kai G., Taira, Takaomi, Zhang, Chencheng, Sun, Bomin, Toda, Hiroki, Schlaepfer, Thomas, Chang, Jin Woo, Regis, Jean, Schuurman, Rick, Schulder, Michael, Doshi, Paresh, Mosley, Philip, Poologaindran, Anujan, Lazaro-Munoz, Gabriel, Pepper, Joshua, Schechtmann, Gaston, Fytagoridis, Anders, Huys, Daniel ORCID: 0000-0002-9124-4128, Goncalves-Ferreira, Antonio, D'haese, Pierre-Francois, Neimat, Joseph, Broggi, Giovanni, Vilela-Filho, Osvaldo, Voges, Juergen, Alkhani, Ahmed, Nakajima, Takeshi, Richieri, Raphaelle, Djurfeldt, Diana, Fontaine, Philippe, Martinez-Alvarez, Roberto, Okamura, Yasushi, Chandler, Jennifer, Watanabe, Katsushige, Barcia, Juan A., Reneses, Blanca, Lozano, Andres ORCID: 0000-0001-8257-3694, Gabriels, Loes, De Salles, Antonio, Halpern, Casey H., Matthews, Keith, Fins, Joseph J. and Nuttin, Bart . Deep brain stimulation for refractory obsessive-compulsive disorder (OCD): emerging or established therapy? Mol. Psychiatr.. LONDON: SPRINGERNATURE. ISSN 1476-5578

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Abstract

A consensus has yet to emerge whether deep brain stimulation (DBS) for treatment-refractory obsessive-compulsive disorder (OCD) can be considered an established therapy. In 2014, the World Society for Stereotactic and Functional Neurosurgery (WSSFN) published consensus guidelines stating that a therapy becomes established when at least two blinded randomized controlled clinical trials from two different groups of researchers are published, both reporting an acceptable risk-benefit ratio, at least comparable with other existing therapies. The clinical trials should be on the same brain area for the same psychiatric indication. The authors have now compiled the available evidence to make a clear statement on whether DBS for OCD is established therapy. Two blinded randomized controlled trials have been published, one with level I evidence (Yale-Brown Obsessive Compulsive Scale (Y-BOCS) score improved 37% during stimulation on), the other with level II evidence (25% improvement). A clinical cohort study (N = 70) showed 40% Y-BOCS score improvement during DBS, and a prospective international multi-center study 42% improvement (N = 30). The WSSFN states that electrical stimulation for otherwise treatment refractory OCD using a multipolar electrode implanted in the ventral anterior capsule region (including bed nucleus of stria terminalis and nucleus accumbens) remains investigational. It represents an emerging, but not yet established therapy. A multidisciplinary team involving psychiatrists and neurosurgeons is a prerequisite for such therapy, and the future of surgical treatment of psychiatric patients remains in the realm of the psychiatrist.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Wu, HemmingsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hariz, MarwanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Visser-Vandewalle, VeerleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zrinzo, LudvicUNSPECIFIEDorcid.org/0000-0002-6013-4946UNSPECIFIED
Coenen, Volker A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sheth, Sameer A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bervoets, ChrisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Naesstrom, MatildaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Blomstedt, PatricUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Coyne, TerryUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hamani, ClementUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Slavin, KonstantinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krauss, Joachim K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kahl, Kai G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Taira, TakaomiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zhang, ChenchengUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sun, BominUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Toda, HirokiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schlaepfer, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chang, Jin WooUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Regis, JeanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schuurman, RickUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schulder, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Doshi, PareshUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mosley, PhilipUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Poologaindran, AnujanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lazaro-Munoz, GabrielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pepper, JoshuaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schechtmann, GastonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fytagoridis, AndersUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Huys, DanielUNSPECIFIEDorcid.org/0000-0002-9124-4128UNSPECIFIED
Goncalves-Ferreira, AntonioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
D'haese, Pierre-FrancoisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Neimat, JosephUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Broggi, GiovanniUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vilela-Filho, OsvaldoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Voges, JuergenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alkhani, AhmedUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nakajima, TakeshiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Richieri, RaphaelleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Djurfeldt, DianaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fontaine, PhilippeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Martinez-Alvarez, RobertoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Okamura, YasushiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chandler, JenniferUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Watanabe, KatsushigeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barcia, Juan A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reneses, BlancaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lozano, AndresUNSPECIFIEDorcid.org/0000-0001-8257-3694UNSPECIFIED
Gabriels, LoesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
De Salles, AntonioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Halpern, Casey H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Matthews, KeithUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fins, Joseph J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nuttin, BartUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-312303
DOI: 10.1038/s41380-020-00933-x
Journal or Publication Title: Mol. Psychiatr.
Publisher: SPRINGERNATURE
Place of Publication: LONDON
ISSN: 1476-5578
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
METHODOLOGICAL ISSUES; NUCLEUSMultiple languages
Biochemistry & Molecular Biology; Neurosciences; PsychiatryMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/31230

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