Jessen, Frank, Kleineidam, Luca, Wolfsgruber, Steffen, Bickel, Horst, Brettschneider, Christian ORCID: 0000-0002-5280-1075, Fuchs, Angela, Kaduszkiewicz, Hanna, Koenig, Hans-Helmut, Mallon, Tina, Mamone, Silke, Pabst, Alexander, Pentzek, Michael, Roehr, Susanne, Weeg, Dagmar, Jochen, Werle, Weyerer, Siegfried, Wiese, Birgitt, Maier, Wolfgang, Scherer, Martin, Riedel-Heller, Steffi and Wagner, Michael . Prediction of dementia of Alzheimer type by different types of subjective cognitive decline. Alzheimers. Dement.. HOBOKEN: WILEY. ISSN 1552-5279

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Abstract

Introduction: Subjective cognitive decline (SCD) is a risk condition for dementia, including dementia of Alzheimer type (DAT). Methods: We report sensitivity, specificity, positive and negative predictive values (PPV, NPV) for conversion to all-cause dementia, and DAT in different SCD types (decline in memory, assocated worries, longitudinal consitency, of the AgeCoDe study (n = 2.402, 12 years follow-up). Results: 82.7% of those converting to any dementia and 84.4% of those converting with DAT at follow-up, reported memory decline and fulfilled criteria of SCD at least at one time point before. SCD with worries at two consecutive time points showed a specificity of 92.2% for any dementia and also for DAT as well as a PPV of 44.3% for any dementia and of 36.9% for DAT at follow-up at the expense of low sensitivity. Discussion: Different SCD subtypes were either sensitive or specific for future allcause dementia and DAT in cognitively unimpaired individuals. Modest PPV of the most specific SCD subtypes were achieved in this low prevalence population.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Jessen, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kleineidam, LucaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wolfsgruber, SteffenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bickel, HorstUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brettschneider, ChristianUNSPECIFIEDorcid.org/0000-0002-5280-1075UNSPECIFIED
Fuchs, AngelaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaduszkiewicz, HannaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koenig, Hans-HelmutUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mallon, TinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mamone, SilkeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pabst, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pentzek, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roehr, SusanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weeg, DagmarUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jochen, WerleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weyerer, SiegfriedUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wiese, BirgittUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maier, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scherer, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Riedel-Heller, SteffiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wagner, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-312389
DOI: 10.1002/alz.12163
Journal or Publication Title: Alzheimers. Dement.
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1552-5279
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
MULTIINFARCT DEMENTIA; STRUCTURED INTERVIEW; IMPAIRMENT; RISK; DIAGNOSIS; ETIOLOGY; ICD-10; SIDAMMultiple languages
Clinical NeurologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/31238

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