Universität zu Köln

Sharma, Kritika ORCID: 0000-0003-0934-6334, Krohne, Tim U. and Busskamp, Volker (2020). The Rise of Retinal Organoids for Vision Research. Int. J. Mol. Sci., 21 (22). BASEL: MDPI. ISSN 1422-0067

Full text not available from this repository.

Abstract

Retinal degenerative diseases lead to irreversible blindness. Decades of research into the cellular and molecular mechanisms of retinal diseases, using either animal models or human cell-derived 2D systems, facilitated the development of several therapeutic interventions. Recently, human stem cell-derived 3D retinal organoids have been developed. These self-organizing 3D organ systems have shown to recapitulate the in vivo human retinogenesis resulting in morphological and functionally similar retinal cell types in vitro. In less than a decade, retinal organoids have assisted in modeling several retinal diseases that were rather difficult to mimic in rodent models. Retinal organoids are also considered as a photoreceptor source for cell transplantation therapies to counteract blindness. Here, we highlight the development and field's improvements of retinal organoids and discuss their application aspects as human disease models, pharmaceutical testbeds, and cell sources for transplantations.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Sharma, Kritika UNSPECIFIED orcid.org/0000-0003-0934-6334 UNSPECIFIED Krohne, Tim U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Busskamp, Volker UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-312967
DOI:	10.3390/ijms21228484
Journal or Publication Title:	Int. J. Mol. Sci.
Volume:	21
Number:	22
Date:	2020
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	1422-0067
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PLURIPOTENT STEM-CELLS; PIGMENT EPITHELIAL-CELLS; IN-VITRO EXPANSION; NEURAL RETINA; DIFFERENTIATION; PATIENT; TRANSPLANTATION; ESTABLISHMENT; FIBROBLASTS; IMPAIRMENT Multiple languages Biochemistry & Molecular Biology; Chemistry, Multidisciplinary Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/31296