Salmanton-Garcia, Jon, Koehler, Philipp ORCID: 0000-0002-7386-7495, Kindo, Anupma, Falces-Romero, Iker, Garcia-Rodriguez, Julio, Racil, Zdenek, Chen, Sharon C-A, Klimko, Nikolai, Desoubeaux, Guillaume, Thompson, George R., III, Benitez-Penuela, Miguel-Angel, Rodriguez, Jose-Yesid, Sheppard, Donald C., Hoenigl, Martin ORCID: 0000-0002-1653-2824, Le Govic, Yohann, Badali, Hamid, Baddley, John W., Chander, Jagdish, Ingram, Paul R., Pakstis, Diana L., Mellinghoff, Sibylle C., Atici, Serkan ORCID: 0000-0002-3329-1866, Cesaro, Simone ORCID: 0000-0002-8698-9547, Chakrabarti, Arunaloke, Dupont, Damien, Gonzalez, Gloria M., Hatvani, Lorant, Herbrecht, Raoul, Klyasova, Galina, Lass-Florl, Cornelia, Mares, Mihai, Mullane, Kathleen, Vinh, Donald C., Wisplinghoff, Hilmar, Lackner, Michaela, Cornely, Oliver A. and Seidel, Danila (2020). Needles in a haystack: Extremely rare invasive fungal infections reported in FungiScope (R)-Global Registry for Emerging Fungal Infections. J. Infect., 81 (5). S. 802 - 816. LONDON: W B SAUNDERS CO LTD. ISSN 1532-2742

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Abstract

Objectives: Emerging invasive fungal infections (IFI) have become a notable challenge. Apart from the more frequently described fusariosis, lomentosporiosis, mucormycosis, scedosporiosis, and certain dematiaceae or yeasts, little is known about extremely rare IFI. Methods: Extremely rare IFI collected in the FungiScope (R) registry were grouped as Dematiaceae, Hypocreales, Saccharomycetales, Eurotiales, Dermatomycetes, Agaricales, and Mucorales. Results: Between 2003 and June 2019, 186 extremely rare IFI were documented in FungiScope (R). Dematiaceae (35.5%), Hypocreales (23.1%), Mucorales (11.8%), and Saccharomycetales (11.3%) caused most IFI. Most patients had an underlying malignancy (38.7%) with acute leukemia accounting for 50% of cancers. Dissemination was observed in 26.9% of the patients. Complete or partial clinical response rate was 68.3%, being highest in Eurotiales (82.4%) and in Agaricales (80.0%). Overall mortality rate was 29.3%, ranging from 11.8% in Eurotiales to 50.0% in Mucorales. Conclusions: Physicians are confronted with a complex variety of fungal pathogens, for which treatment recommendations are lacking and successful outcome might be incidental. Through an international consortium of physicians and scientists, these cases of extremely rare IFI can be collected to further investigate their epidemiology and eventually identify effective treatment regimens. (C) 2020 The British Infection Association. Published by Elsevier Ltd. All rights reserved.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Salmanton-Garcia, JonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koehler, PhilippUNSPECIFIEDorcid.org/0000-0002-7386-7495UNSPECIFIED
Kindo, AnupmaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Falces-Romero, IkerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Garcia-Rodriguez, JulioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Racil, ZdenekUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chen, Sharon C-AUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klimko, NikolaiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Desoubeaux, GuillaumeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thompson, George R., IIIUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Benitez-Penuela, Miguel-AngelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rodriguez, Jose-YesidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sheppard, Donald C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoenigl, MartinUNSPECIFIEDorcid.org/0000-0002-1653-2824UNSPECIFIED
Le Govic, YohannUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Badali, HamidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baddley, John W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chander, JagdishUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ingram, Paul R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pakstis, Diana L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mellinghoff, Sibylle C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Atici, SerkanUNSPECIFIEDorcid.org/0000-0002-3329-1866UNSPECIFIED
Cesaro, SimoneUNSPECIFIEDorcid.org/0000-0002-8698-9547UNSPECIFIED
Chakrabarti, ArunalokeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dupont, DamienUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gonzalez, Gloria M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hatvani, LorantUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Herbrecht, RaoulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klyasova, GalinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lass-Florl, CorneliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mares, MihaiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mullane, KathleenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vinh, Donald C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wisplinghoff, HilmarUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lackner, MichaelaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cornely, Oliver A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seidel, DanilaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-312975
DOI: 10.1016/j.jinf.2020.08.015
Journal or Publication Title: J. Infect.
Volume: 81
Number: 5
Page Range: S. 802 - 816
Date: 2020
Publisher: W B SAUNDERS CO LTD
Place of Publication: LONDON
ISSN: 1532-2742
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
JOINT CLINICAL GUIDELINES; TRANSPLANT RECIPIENTS; SCEDOSPORIUM SPP.; PHEOHYPHOMYCOSIS; MANAGEMENT; DIAGNOSIS; SURVEILLANCE; MULTICENTER; FUSARIOSIS; RESPONSESMultiple languages
Infectious DiseasesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/31297

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