Chetelat, Gael, Arbizu, Javier, Barthel, Henryk, Garibotto, Valentina ORCID: 0000-0003-2422-698X, Law, Ian, Morbelli, Silvia, van de Giessen, Elsmarieke, Agosta, Federica, Barkhof, Frederik ORCID: 0000-0003-3543-3706, Brooks, David J., Carrillo, Maria C., Dubois, Bruno, Fjell, Anders M., Frisoni, Giovanni B., Hansson, Oskar, Herholz, Karl, Hutton, Brian F., Jack, Clifford R., Jr., Lammertsma, Adriaan A., Landau, Susan M., Minoshima, Satoshi, Nobili, Flavio, Nordberg, Agneta, Ossenkoppele, Rik, Oyen, Wim J. G., Perani, Daniela, Rabinovici, Gil D., Scheltens, Philip, Villemagne, Victor L., Zetterberg, Henrik and Drzezga, Alexander (2020). Amyloid-PET and F-18-FDG-PET in the diagnostic investigation of Alzheimer's disease and other dementias. Lancet Neurol., 19 (11). S. 951 - 963. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1474-4465

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Abstract

Various biomarkers are available to support the diagnosis of neurodegenerative diseases in clinical and research settings. Among the molecular imaging biomarkers, amyloid-PET, which assesses brain amyloid deposition, and F-18-fluorodeoxyglucose (F-18-FDG) PET, which assesses glucose metabolism, provide valuable and complementary information. However, uncertainty remains regarding the optimal timepoint, combination, and an order in which these PET biomarkers should be used in diagnostic evaluations because conclusive evidence is missing. Following an expert panel discussion, we reached an agreement on the specific use of the individual biomarkers, based on available evidence and clinical expertise. We propose a diagnostic algorithm with optimal timepoints for these PET biomarkers, also taking into account evidence from other biomarkers, for early and differential diagnosis of neurodegenerative diseases that can lead to dementia. We propose three main diagnostic pathways with distinct biomarker sequences, in which amyloid-PET and F-18-FDG-PET are placed at different positions in the order of diagnostic evaluations, depending on clinical presentation. We hope that this algorithm can support diagnostic decision making in specialist clinical settings with access to these biomarkers and might stimulate further research towards optimal diagnostic strategies.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Chetelat, GaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arbizu, JavierUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barthel, HenrykUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Garibotto, ValentinaUNSPECIFIEDorcid.org/0000-0003-2422-698XUNSPECIFIED
Law, IanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Morbelli, SilviaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van de Giessen, ElsmariekeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Agosta, FedericaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barkhof, FrederikUNSPECIFIEDorcid.org/0000-0003-3543-3706UNSPECIFIED
Brooks, David J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Carrillo, Maria C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dubois, BrunoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fjell, Anders M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Frisoni, Giovanni B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hansson, OskarUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Herholz, KarlUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hutton, Brian F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jack, Clifford R., Jr.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lammertsma, Adriaan A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Landau, Susan M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Minoshima, SatoshiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nobili, FlavioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nordberg, AgnetaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ossenkoppele, RikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Oyen, Wim J. G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Perani, DanielaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rabinovici, Gil D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scheltens, PhilipUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Villemagne, Victor L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zetterberg, HenrikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Drzezga, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-313646
Journal or Publication Title: Lancet Neurol.
Volume: 19
Number: 11
Page Range: S. 951 - 963
Date: 2020
Publisher: ELSEVIER SCIENCE INC
Place of Publication: NEW YORK
ISSN: 1474-4465
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
MILD COGNITIVE IMPAIRMENT; PROGRESSIVE SUPRANUCLEAR PALSY; CEREBROSPINAL-FLUID BIOMARKERS; POSITRON-EMISSION-TOMOGRAPHY; DIFFERENTIAL-DIAGNOSIS; CLINICAL-DIAGNOSIS; NATIONAL INSTITUTE; CSF BIOMARKERS; FDG-PET; A-BETAMultiple languages
Clinical NeurologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/31364

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