Pollak, Thomas A., Kempton, Matthew J., Iyegbe, Conrad, Vincent, Angela ORCID: 0000-0003-2395-8695, Irani, Sarosh R., Coutinho, Ester, Menassa, David A., Jacobson, Leslie, de Haan, Lieuwe, Ruhrmann, Stephan, Sachs, Gabriele ORCID: 0000-0002-8359-9877, Riecher-Roessler, Anita, Krebs, Marie-Odile, Amminger, Paul, Glenthoj, Birte, Barrantes-Vidal, Neus ORCID: 0000-0002-8671-1238, van Os, Jim, Rutten, Bart P. F., Bressan, Rodrigo A., van der Gaag, Mark, Yolken, Robert, Hotopf, Matthew, Valmaggia, Lucia ORCID: 0000-0001-6099-8464, Stone, James ORCID: 0000-0003-3051-0135, David, Anthony S., McGuire, Philip ORCID: 0000-0003-4381-0532, Calem, Maria, Tognin, Stefania, Modinos, Gemma, de Haan, Lieuwe, van der Gaag, Mark, Velthorst, Eva, Kraan, Tamar C., van Dam, Daniella S., Burger, Nadine, Nelson, Barnaby, McGorry, Patrick, Amminger, Paul, Pantelis, Christos ORCID: 0000-0002-9565-0238, Politis, Athena, Goodall, Joanne, Riecher-Roessler, Anita, Borgwardt, Stefan, Ittig, Sarah, Studerus, Erich, Smieskova, Renata, Bressan, Rodrigo A., Gadelha, Ary, Brietzke, Elisa ORCID: 0000-0003-2697-1342, Asevedo, Graccielle, Asevedo, Elson, Zugman, Andre, Barrantes-Vidal, Neus ORCID: 0000-0002-8671-1238, Rosa, Araceli, Racioppi, Anna ORCID: 0000-0002-5575-2811, Monsonet, Manel, Hinojosa-Marques, Lidia, Kwapil, Thomas R., Kazes, Mathilde, Daban, Claire, Bourgin, Julie, Gay, Olivier, Mam-Lam-Fook, Celia, Krebs, Marie-Odile, Nordholm, Dorte, Randers, Lasse, Krakauer, Kristine, Glenthoj, Louise, Glenthoj, Birte, Nordentoft, Merete, Ruhrmann, Stephan, Gebhard, Dominika, Arnhold, Julia, Klosterkoetter, Joachim, Sachs, Gabriele ORCID: 0000-0002-8359-9877, Lasser, Iris, Winklbaur, Bernadette, Delespaul, Philippe A., Rutten, Bart P. F. and van Os, Jim . Clinical, cognitive and neuroanatomical associations of serum NMDAR autoantibodies in people at clinical high risk for psychosis. Mol. Psychiatr.. LONDON: SPRINGERNATURE. ISSN 1476-5578

Full text not available from this repository.

Abstract

Serum neuronal autoantibodies, such as those to the NMDA receptor (NMDAR), are detectable in a subgroup of patients with psychotic disorders. It is not known if they are present before the onset of psychosis or whether they are associated with particular clinical features or outcomes. In a case-control study, sera from 254 subjects at clinical high risk (CHR) for psychosis and 116 healthy volunteers were tested for antibodies against multiple neuronal antigens implicated in CNS autoimmune disorders, using fixed and live cell-based assays (CBAs). Within the CHR group, the relationship between NMDAR antibodies and symptoms, cognitive function and clinical outcomes over 24 month follow-up was examined. CHR subjects were not more frequently seropositive for neuronal autoantibodies than controls (8.3% vs. 5.2%; OR = 1.50; 95% CI: 0.58-3.90). The NMDAR was the most common target antigen and NMDAR IgGs were more sensitively detected with live versus fixed CBAs (p < 0.001). Preliminary phenotypic analyses revealed that within the CHR sample, the NMDAR antibody seropositive subjects had higher levels of current depression, performed worse on the Rey Auditory Verbal Learning Task (p < 0.05), and had a markedly lower IQ (p < 0.01). NMDAR IgGs were not more frequent in subjects who later became psychotic than those who did not. NMDAR antibody serostatus and titre was associated with poorer levels of functioning at follow-up (p < 0.05) and the presence of a neuronal autoantibody was associated with larger amygdala volumes (p < 0.05). Altogether, these findings demonstrate that NMDAR autoantibodies are detectable in a subgroup of CHR subjects at equal rates to controls. In the CHR group, they are associated with affective psychopathology, impairments in verbal memory, and overall cognitive function: these findings are qualitatively and individually similar to core features of autoimmune encephalitis and/or animal models of NMDAR antibody-mediated CNS disease. Overall the current work supports further evaluation of NMDAR autoantibodies as a possible prognostic biomarker and aetiological factor in a subset of people already meeting CHR criteria.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Pollak, Thomas A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kempton, Matthew J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Iyegbe, ConradUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vincent, AngelaUNSPECIFIEDorcid.org/0000-0003-2395-8695UNSPECIFIED
Irani, Sarosh R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Coutinho, EsterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Menassa, David A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jacobson, LeslieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Haan, LieuweUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruhrmann, StephanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sachs, GabrieleUNSPECIFIEDorcid.org/0000-0002-8359-9877UNSPECIFIED
Riecher-Roessler, AnitaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krebs, Marie-OdileUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Amminger, PaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Glenthoj, BirteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barrantes-Vidal, NeusUNSPECIFIEDorcid.org/0000-0002-8671-1238UNSPECIFIED
van Os, JimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rutten, Bart P. F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bressan, Rodrigo A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van der Gaag, MarkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yolken, RobertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hotopf, MatthewUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Valmaggia, LuciaUNSPECIFIEDorcid.org/0000-0001-6099-8464UNSPECIFIED
Stone, JamesUNSPECIFIEDorcid.org/0000-0003-3051-0135UNSPECIFIED
David, Anthony S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
McGuire, PhilipUNSPECIFIEDorcid.org/0000-0003-4381-0532UNSPECIFIED
Calem, MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tognin, StefaniaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Modinos, GemmaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Haan, LieuweUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van der Gaag, MarkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Velthorst, EvaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kraan, Tamar C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Dam, Daniella S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Burger, NadineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nelson, BarnabyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
McGorry, PatrickUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Amminger, PaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pantelis, ChristosUNSPECIFIEDorcid.org/0000-0002-9565-0238UNSPECIFIED
Politis, AthenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goodall, JoanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Riecher-Roessler, AnitaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Borgwardt, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ittig, SarahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Studerus, ErichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Smieskova, RenataUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bressan, Rodrigo A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gadelha, AryUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brietzke, ElisaUNSPECIFIEDorcid.org/0000-0003-2697-1342UNSPECIFIED
Asevedo, GraccielleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Asevedo, ElsonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zugman, AndreUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barrantes-Vidal, NeusUNSPECIFIEDorcid.org/0000-0002-8671-1238UNSPECIFIED
Rosa, AraceliUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Racioppi, AnnaUNSPECIFIEDorcid.org/0000-0002-5575-2811UNSPECIFIED
Monsonet, ManelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hinojosa-Marques, LidiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kwapil, Thomas R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kazes, MathildeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Daban, ClaireUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bourgin, JulieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gay, OlivierUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mam-Lam-Fook, CeliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krebs, Marie-OdileUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nordholm, DorteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Randers, LasseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krakauer, KristineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Glenthoj, LouiseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Glenthoj, BirteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nordentoft, MereteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruhrmann, StephanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gebhard, DominikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arnhold, JuliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klosterkoetter, JoachimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sachs, GabrieleUNSPECIFIEDorcid.org/0000-0002-8359-9877UNSPECIFIED
Lasser, IrisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Winklbaur, BernadetteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Delespaul, Philippe A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rutten, Bart P. F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Os, JimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-314673
DOI: 10.1038/s41380-020-00899-w
Journal or Publication Title: Mol. Psychiatr.
Publisher: SPRINGERNATURE
Place of Publication: LONDON
ISSN: 1476-5578
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
ASPARTATE RECEPTOR AUTOANTIBODIES; 1ST-EPISODE PSYCHOSIS; NEURONAL AUTOANTIBODIES; LIMBIC ENCEPHALITIS; RATING-SCALE; MENTAL STATE; HIPPOCAMPAL; ANTIBODIES; BRAIN; INDIVIDUALSMultiple languages
Biochemistry & Molecular Biology; Neurosciences; PsychiatryMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/31467

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item