Universität zu Köln

Gracheva, Iuliia A., Shchegravina, Ekaterina S., Schmalz, Hans-Gunther ORCID: 0000-0003-0489-1827, Beletskaya, Irina P. and Fedorov, Alexey Yu (2020). Colchicine Alkaloids and Synthetic Analogues: Current Progress and Perspectives. J. Med. Chem., 63 (19). S. 10618 - 10652. WASHINGTON: AMER CHEMICAL SOC. ISSN 1520-4804

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Abstract

Colchicine, the main alkaloid of Colchicum autumnale, is one of the most famous natural molecules. Although colchicine belongs to the oldest drugs (in use since 1500 BC), its pharmacological potential as a lead structure is not yet fully exploited. This review is devoted to the synthesis and structure-activity relationships (SAR) of colchicine alkaloids and their analogues with modified A, B, and C rings, as well as hybrid compounds derived from colchicinoids including prodrugs, conjugates, and delivery systems. The systematization of a vast amount of information presented to date will create a paradigm for future studies of colchicinoids for neoplastic and various other diseases.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Gracheva, Iuliia A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Shchegravina, Ekaterina S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmalz, Hans-Gunther UNSPECIFIED orcid.org/0000-0003-0489-1827 UNSPECIFIED Beletskaya, Irina P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fedorov, Alexey Yu UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-315391
DOI:	10.1021/acs.jmedchem.0c00222
Journal or Publication Title:	J. Med. Chem.
Volume:	63
Number:	19
Page Range:	S. 10618 - 10652
Date:	2020
Publisher:	AMER CHEMICAL SOC
Place of Publication:	WASHINGTON
ISSN:	1520-4804
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Chemistry > Institute of Organic Chemistry
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ENANTIOSELECTIVE TOTAL-SYNTHESIS; VASCULAR DISRUPTING AGENT; III BETA-TUBULIN; B-RING ANALOGS; O-METHYL ETHER; BIOLOGICAL EVALUATION; ANTITUMOR AGENTS; C-RING; N-ACETYLCOLCHINOL; 4-CHLOROCOLCHICINE DERIVATIVES Multiple languages Chemistry, Medicinal Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/31539