Universität zu Köln

Moeller, M. and Brinkkoetter, P. (2020). Minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS) Diagnostics and treatment. Nephrologe, 15 (6). S. 347 - 356. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1862-0418

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Abstract

Minimal change disease (MCD) and primary focal segmental glomerulosclerosis (FSGS) are rare diseases that are usually manifested with a nephrotic syndrome and are most likely caused by an as yet unknown permeability factor. While MCD by definition has not yet led to a loss of renal function, FSGS is characterized by the formation of glomerular scars with progressive chronic renal insufficiency. It is important to note that in FSGS the isolated detection of these scars (lesions) in the biopsy is not sufficient for the diagnosis of primary FSGS. Relevant differential diagnoses (adaptive FSGS and genetic FSGS) appear identical under the light microscope, but they can be distinguished on the basis of the clinical picture (especially by the nephrotic syndrome). Therapeutically, the effectiveness of a consistent supportive treatment and especially a well-adjusted blood pressure is generally underestimated. With this treatment the progressive loss of renal function can be effectively slowed down or stopped. In MCD and primary FSGS with nephrotic syndrome immunosuppressive treatment is indicated, mostly using high-dose glucocorticoids and over prolonged periods of time. We recommend referring patients to specialized outpatient clinics, which can be helpful with their experience in diagnostics and treatment and, if necessary, inclusion in clinical trials.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Moeller, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Brinkkoetter, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-315486
DOI:	10.1007/s11560-020-00458-y
Journal or Publication Title:	Nephrologe
Volume:	15
Number:	6
Page Range:	S. 347 - 356
Date:	2020
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1862-0418
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CHANGE NEPHROTIC SYNDROME; RANDOMIZED-TRIAL; CLINICAL-COURSE; ADULTS; ONSET; CYCLOSPORINE; RESISTANT; TACROLIMUS; THERAPY Multiple languages Urology & Nephrology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/31548