Pennig, Lenhard, Kabbasch, Christoph, Hoyer, Ulrike Cornelia Isabel, Lennartz, Simon, Zopfs, David, Goertz, Lukas, Laukamp, Kai Roman, Wagner, Anton, Grunz, Jan-Peter, Doerner, Jonas, Persigehl, Thorsten, Weiss, Kilian and Borggrefe, Jan ORCID: 0000-0003-2908-7560 . Relaxation-Enhanced Angiography Without Contrast and Triggering (REACT) for Fast Imaging of Extracranial Arteries in Acute Ischemic Stroke at 3T. Clin. Neuroradiol.. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1869-1447

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Abstract

Purpose To evaluate a novel flow-independent 3D isotropic REACT sequence compared with CE-MRA for the imaging of extracranial arteries in acute ischemic stroke (AIS). Methods This was a retrospective study of 35 patients who underwent a stroke protocol at 3T including REACT (fixed scan time: 2:46 min) and CE-MRA of the extracranial arteries. Three radiologists evaluated scans regarding vessel delineation, signal, and contrast and assessed overall image noise and artifacts using 5-point scales (5: excellent delineation/no artifacts). Apparent signal- and contrast-to-noise ratios ( aSNR/aCNR) were measured for the common carotid artery (CCA), internal carotid artery (ICA, C1 segment), and vertebral artery ( V2 segment). Two radiologists graded the degree of proximal ICA stenosis. Results Compared to REACT, CE-MRA showed better delineation for the CCA and ICA (C1 and C2 segments) (median 5, range 2-5 vs. 4, range 3-5; P< 0.05). For the ICA (C1 and C2 segments), REACT provided a higher signal (5, range 3-5; P< 0.05/4.5, range 3-5; P> 0.05 vs. 4, range 2-5) and contrast (5, range 3-5 vs. 4, range 2-5; P> 0.05) than CE-MRA. The remaining segments of the blood-supplying vessels showed equal medians. There was no significant difference regarding artifacts, whereas REACT provided significantly lower image noise (4, range 3-5 vs. 4 range 2-5; P< 0.05) with a higher aSNR (P< 0.05) and aCNR (P< 0.05) for all vessels combined. For clinically relevant (=50%) ICA stenosis, REACT achieved a detection sensitivity of 93.75% and a specificity of 100%. Conclusion Given its fast acquisition, comparable image quality to CE-MRA and high sensitivity and specificity for the detection of ICA stenosis, REACT was proven to be a clinically applicable method to assess extracranial arteries in AIS.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Pennig, LenhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kabbasch, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoyer, Ulrike Cornelia IsabelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lennartz, SimonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zopfs, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goertz, LukasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Laukamp, Kai RomanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wagner, AntonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grunz, Jan-PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Doerner, JonasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Persigehl, ThorstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weiss, KilianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Borggrefe, JanUNSPECIFIEDorcid.org/0000-0003-2908-7560UNSPECIFIED
URN: urn:nbn:de:hbz:38-315572
DOI: 10.1007/s00062-020-00963-6
Journal or Publication Title: Clin. Neuroradiol.
Publisher: SPRINGER HEIDELBERG
Place of Publication: HEIDELBERG
ISSN: 1869-1447
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
MAGNETIC-RESONANCE ANGIOGRAPHY; MR-ANGIOGRAPHY; SUPRAAORTIC ARTERIES; DIAGNOSTIC-ACCURACY; GADOLINIUM; DISEASE; RESOLUTION; SENSEMultiple languages
Clinical Neurology; Radiology, Nuclear Medicine & Medical ImagingMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/31557

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