Universität zu Köln

Buxhofer-Ausch, Veronika, Wolf, Dominik, Sormann, Siegfried, Forjan, Ernst, Schimetta, Wolfgang, Gisslinger, Bettina, Heibl, Sonja, Krauth, Maria Theresa, Thiele, Juergen, Ruckser, Reinhard and Gisslinger, Heinz (2021). Impact of platelets on major thrombosis in patients with a normal white blood cell count in essential thrombocythemia. Eur. J. Haematol., 106 (1). S. 58 - 64. HOBOKEN: WILEY. ISSN 1600-0609

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Abstract

Objectives Cell counts have a significant impact on the complex mechanism of thrombosis in patients with essential thrombocythemia (ET). We recently demonstrated a considerable impact of white blood cell (WBC) counts on thrombotic risk in patients with optimized platelet counts by analysing a large anagrelide registry. In contrast, the current analysis of the registry aimed to estimate the influence of platelet counts on thrombotic risk in patients with optimized WBC counts. Methods Cox regression analysis and Kaplan-Meier plot were applied on all patients in the registry with optimized WBC counts. Results By using the calculated cut-off of 593 G/L for platelets, Cox regression analysis revealed a clear influence of elevated platelet counts on the occurrence of a major thrombotic event (P < .001). A Kaplan-Meier plot revealed a markedly shorter time to a major thrombotic event for patients with platelet counts above the cut-off (P < .001). Conclusions The data show clear impact of platelet lowering on the thrombotic risk in ET patients with normal WBC counts. Therefore, selective platelet lowering with anagrelide appears sufficient for thrombotic risk reduction in WHO-diagnosed ET patients lacking leukocytosis.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Buxhofer-Ausch, Veronika UNSPECIFIED UNSPECIFIED UNSPECIFIED Wolf, Dominik UNSPECIFIED UNSPECIFIED UNSPECIFIED Sormann, Siegfried UNSPECIFIED UNSPECIFIED UNSPECIFIED Forjan, Ernst UNSPECIFIED UNSPECIFIED UNSPECIFIED Schimetta, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Gisslinger, Bettina UNSPECIFIED UNSPECIFIED UNSPECIFIED Heibl, Sonja UNSPECIFIED UNSPECIFIED UNSPECIFIED Krauth, Maria Theresa UNSPECIFIED UNSPECIFIED UNSPECIFIED Thiele, Juergen UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruckser, Reinhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Gisslinger, Heinz UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-315712
DOI:	10.1111/ejh.13516
Journal or Publication Title:	Eur. J. Haematol.
Volume:	106
Number:	1
Page Range:	S. 58 - 64
Date:	2021
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1600-0609
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language POLYCYTHEMIA-VERA; MYELOPROLIFERATIVE NEOPLASMS; CLINICAL-EVALUATION; RESPONSE CRITERIA; 2ND CANCERS; ANAGRELIDE; RISK; INTERFERON; EFFICACY; HYDROXYCARBAMIDE Multiple languages Hematology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/31571