Tichelbaecker, Tobias, Scherner, L., Puls, M., Schillinger, W., Adler, C., Baldus, S., Jacobshagen, C. and Huenlich, M. (2020). Midterm outcomes of LAA occlusion with the AMPLATZER Cardiac Plug and AMPLATZER Amulet devices in a high-risk cohort. Sci Rep, 10 (1). BERLIN: NATURE RESEARCH. ISSN 2045-2322

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Abstract

LAA occlusion has become a favourable option in patients with atrial fibrillation not eligible for oral anticoagulation therapy. Proof of effectiveness of LAA closure devices in a midterm follow-up period. This retrospective single-center cohort study analysed outcome in patients treated with AMPLATZER Cardiac Plug or AMPLATZER Amulet device. A standardized follow-up by phone call focusing on data of death, stroke and bleeding events was performed. Routine antiplatelet strategy was DAPT for 3 months post procedural. 212 patients (mean age 77 +/- 6 years) were included. Follow up was performed in 197 (93%) patients. Patients were at high risk for thromboembolic or bleeding events (prior stroke/TIA 29%; prior bleeding 54%. Overall, there was a mean follow-up period of 1244.2 days (+/- 756.7) and a total of 674 patient years. We observed 25 events later than day 8 post procedure. We were able to demonstrate a high effectiveness of the AMPLATZER Cardiac Plug/AMPLATZER Amulet devices regarding the prevention of stroke and bleedings in a high-risk real-world cohort during a midterm follow-up period. Overall, we observed remarkably lower rates of stroke and bleedings as predicted with CHA(2)DS(2)-VASc and HASBLED scores.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Tichelbaecker, TobiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scherner, L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Puls, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schillinger, W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Adler, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baldus, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jacobshagen, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Huenlich, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-316843
DOI: 10.1038/s41598-020-73381-w
Journal or Publication Title: Sci Rep
Volume: 10
Number: 1
Date: 2020
Publisher: NATURE RESEARCH
Place of Publication: BERLIN
ISSN: 2045-2322
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
ATRIAL APPENDAGE CLOSURE; WARFARINMultiple languages
Multidisciplinary SciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/31684

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