Universität zu Köln

Wang, Xiaoqi, Huang, Weijie, Su, Li, Xing, Yue, Jessen, Frank, Sun, Yu, Shu, Ni and Han, Ying ORCID: 0000-0003-0377-7424 (2020). Neuroimaging advances regarding subjective cognitive decline in preclinical Alzheimer's disease. Mol. Neurodegener., 15 (1). LONDON: BMC. ISSN 1750-1326

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Abstract

Subjective cognitive decline (SCD) is regarded as the first clinical manifestation in the Alzheimer's disease (AD) continuum. Investigating populations with SCD is important for understanding the early pathological mechanisms of AD and identifying SCD-related biomarkers, which are critical for the early detection of AD. With the advent of advanced neuroimaging techniques, such as positron emission tomography (PET) and magnetic resonance imaging (MRI), accumulating evidence has revealed structural and functional brain alterations related to the symptoms of SCD. In this review, we summarize the main imaging features and key findings regarding SCD related to AD, from local and regional data to connectivity-based imaging measures, with the aim of delineating a multimodal imaging signature of SCD due to AD. Additionally, the interaction of SCD with other risk factors for dementia due to AD, such as age and theApolipoprotein E(ApoE) e4 status, has also been described. Finally, the possible explanations for the inconsistent and heterogeneous neuroimaging findings observed in individuals with SCD are discussed, along with future directions. Overall, the literature reveals a preferential vulnerability of AD signature regions in SCD in the context of AD, supporting the notion that individuals with SCD share a similar pattern of brain alterations with patients with mild cognitive impairment (MCI) and dementia due to AD. We conclude that these neuroimaging techniques, particularly multimodal neuroimaging techniques, have great potential for identifying the underlying pathological alterations associated with SCD. More longitudinal studies with larger sample sizes combined with more advanced imaging modeling approaches such as artificial intelligence are still warranted to establish their clinical utility.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wang, Xiaoqi UNSPECIFIED UNSPECIFIED UNSPECIFIED Huang, Weijie UNSPECIFIED UNSPECIFIED UNSPECIFIED Su, Li UNSPECIFIED UNSPECIFIED UNSPECIFIED Xing, Yue UNSPECIFIED UNSPECIFIED UNSPECIFIED Jessen, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Sun, Yu UNSPECIFIED UNSPECIFIED UNSPECIFIED Shu, Ni UNSPECIFIED UNSPECIFIED UNSPECIFIED Han, Ying UNSPECIFIED orcid.org/0000-0003-0377-7424 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-318619
DOI:	10.1186/s13024-020-00395-3
Journal or Publication Title:	Mol. Neurodegener.
Volume:	15
Number:	1
Date:	2020
Publisher:	BMC
Place of Publication:	LONDON
ISSN:	1750-1326
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CEREBRAL-BLOOD-FLOW; MEDIAL TEMPORAL-LOBE; DEFAULT-MODE NETWORK; APOE EPSILON-4 CARRIERS; WHITE-MATTER INTEGRITY; NORMAL OLDER-ADULTS; MIDDLE-AGED ADULTS; MEMORY COMPLAINTS; AMYLOID-BETA; FUNCTIONAL CONNECTIVITY Multiple languages Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/31861