Universität zu Köln

Frett, Timo, Green, David Andrew, Mulder, Edwin, Noppe, Alexandra, Arz, Michael, Pustowalow, Willi, Petrat, Guido, Tegtbur, Uwe and Jordan, Jens (2020). Tolerability of daily intermittent or continuous short-arm centrifugation during 60-day 6(o) head down bed rest (AGBRESA study). PLoS One, 15 (9). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

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Abstract

Artificial gravity through short-arm centrifugation has potential as a multi-system countermeasure for deconditioning and cranial fluid shifts that may underlie ocular issues in microgravity. However, the optimal short-arm centrifugation protocol that is effective whilst remaining tolerable has yet to be determined. Given that exposure to centrifugation is associated with presyncope and syncope and in addition motion sickness an intermittent protocol has been suggested to be more tolerable. Therefore, we assessed cardiovascular loading and subjective tolerability of daily short arm centrifugation with either an intermittent or a continuous protocol during long-term head-down bed rest as model for microgravity exposure in a mixed sex cohort. During the Artificial Gravity Bed Rest with European Space Agency (AGBRESA) 60 day 6 degrees head down tilt bed rest study we compared the tolerability of daily +1Gzexposure at the center of mass centrifugation, either performed continuously for 30 minutes, or intermittedly (6 x 5 minutes). Heart rate and blood pressure were assessed daily during centrifugation along with post motion sickness scoring and rate of perceived exertion. During bed rest, 16 subjects (6 women, 10 men), underwent 960 centrifuge runs in total. Ten centrifuge runs had to be terminated prematurely, 8 continuous runs and 2 intermittent runs, mostly due to pre-syncopal symptoms and not motion sickness. All subjects were, however, able to resume centrifuge training on subsequent days. We conclude that both continuous and intermittent short-arm centrifugation protocols providing artificial gravity equivalent to +1Gzat the center of mass is tolerable in terms of cardiovascular loading and motion sickness during long-term head down tilt bed rest. However, intermittent centrifugation appears marginally better tolerated, albeit differences appear minor.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Frett, Timo UNSPECIFIED UNSPECIFIED UNSPECIFIED Green, David Andrew UNSPECIFIED UNSPECIFIED UNSPECIFIED Mulder, Edwin UNSPECIFIED UNSPECIFIED UNSPECIFIED Noppe, Alexandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Arz, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Pustowalow, Willi UNSPECIFIED UNSPECIFIED UNSPECIFIED Petrat, Guido UNSPECIFIED UNSPECIFIED UNSPECIFIED Tegtbur, Uwe UNSPECIFIED UNSPECIFIED UNSPECIFIED Jordan, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-318858
DOI:	10.1371/journal.pone.0239228
Journal or Publication Title:	PLoS One
Volume:	15
Number:	9
Date:	2020
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1932-6203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MOTION SICKNESS ADAPTATION; SOPITE SYNDROME; ORTHOSTATIC INTOLERANCE; ARTIFICIAL GRAVITY; GENDER-DIFFERENCES; FLIGHT; MOVEMENTS; SPACE; SPACEFLIGHT; ASTRONAUTS Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/31885